ml390

2029049-79-2

CAS-Nr.: 2029049-79-2

Englisch Name:: ml390

Synonyma:: ml390;(R)-N-(3-Oxo-3-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)propyl)-4-(trifluoromethoxy)benzamide;Benzamide, N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]propyl]-4-(trifluoromethoxy)-;ER-HoxA9,Dihydroorotate Dehydrogenase,inhibit,AML,ML 390,differentiatio,U937,DHODH,ML390,myeloid,ML-390,Inhibitor,THP1

CBNumber:: CB43145908

Summenformel:: C21H21F3N2O3

Molgewicht:: 406.4

MOL-Datei:: 2029049-79-2.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 37

ml390 Eigenschaften

Siedepunkt:: 599.7±50.0 °C(Predicted)

Dichte: 1.31±0.1 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: ≥40.6 mg/mL in DMSO; insoluble in H2O; ≥17.47 mg/mL in EtOH

Aggregatzustand: solid

pka: 13.65±0.46(Predicted)

Sicherheit

ml390 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

ML-390 is an inhibitor of dihydroorotate dehydrogenase (DHODH), the enzyme that converts dihydroorotate to orotate during de novo pyrimidine synthesis. In acute myeloid leukemia, leukemic myeloblast development is halted at an immature stage leading to perpetual self-renewal rather than differentiation. ML-390 induces differentiation in the acute myeloid leukemia cell lines U937 (murine) and THP-1 (human) cell lines with an EC₅₀ value of approximately 2 μM.

ml390 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ml390 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 37)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Beckham Medical Technology Co., Ltd	021-13816613772 13816613772	huahero21@sina.com	China	367	55
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9854	58
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 4009686088	3193328036@qq.com	China	29795	68
Twochem Co.Ltd.	021-58111628 15800915896		China	1988	58
Guangzhou Tomums Life Science Co., Ltd.	020-31155029 18902330969	sales@tomums.cn	China	4698	58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.	18081075745	chemflowtech@sina.com	China	1886	58

ml390
Benzamide, N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]propyl]-4-(trifluoromethoxy)-
ER-HoxA9,Dihydroorotate Dehydrogenase,inhibit,AML,ML 390,differentiatio,U937,DHODH,ML390,myeloid,ML-390,Inhibitor,THP1
(R)-N-(3-Oxo-3-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)propyl)-4-(trifluoromethoxy)benzamide
2029049-79-2