ml390

ml390 구조식 이미지
카스 번호:
2029049-79-2
상품명:
ml390
동의어(영문):
ml390;(R)-N-(3-Oxo-3-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)propyl)-4-(trifluoromethoxy)benzamide;Benzamide, N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]propyl]-4-(trifluoromethoxy)-;ER-HoxA9,Dihydroorotate Dehydrogenase,inhibit,AML,ML 390,differentiatio,U937,DHODH,ML390,myeloid,ML-390,Inhibitor,THP1
CBNumber:
CB43145908
분자식:
C21H21F3N2O3
포뮬러 무게:
406.4
MOL 파일:
2029049-79-2.mol

ml390 속성

끓는 점
599.7±50.0 °C(Predicted)
밀도
1.31±0.1 g/cm3(Predicted)
저장 조건
Store at -20°C
용해도
≥40.6 mg/mL in DMSO; insoluble in H2O; ≥17.47 mg/mL in EtOH
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
13.65±0.46(Predicted)
색상
White to off-white

안전

ml390 C화학적 특성, 용도, 생산

개요

ML-390 is an inhibitor of dihydroorotate dehydrogenase (DHODH), the enzyme that converts dihydroorotate to orotate during de novo pyrimidine synthesis. In acute myeloid leukemia, leukemic myeloblast development is halted at an immature stage leading to perpetual self-renewal rather than differentiation. ML-390 induces differentiation in the acute myeloid leukemia cell lines U937 (murine) and THP-1 (human) cell lines with an EC50 value of approximately 2 μM.

ml390 준비 용품 및 원자재

원자재

준비 용품


ml390 공급 업체

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