6-Gingerol
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- CAS-Nr.
- 23513-14-6
- Englisch Name:
- 6-Gingerol
- Synonyma:
- GINGEROL;Gingerols;rac-(R*)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decane-3-one;6-GINGEROL;GINGEROL [6];(s)-3-decanon;6-Gingerol ,98%;6-Gingerol std.;[6]-Gingerol>(s)-(6)-gingerol
- CBNumber:
- CB4328683
- Summenformel:
- C17H26O4
- Molgewicht:
- 294.39
- MOL-Datei:
- 23513-14-6.mol
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6-Gingerol Eigenschaften
- Schmelzpunkt:
- 31℃
- Siedepunkt:
- 453.0±35.0 °C(Predicted)
- Dichte
- 1.083±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- Löslichkeit
- methanol: soluble1mg/mL, clear, colorless
- Aggregatzustand
- Pale yellow oil
- pka
- 10.02±0.20(Predicted)
- Farbe
- White to Light yellow
- InChI
- InChI=1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1
- InChIKey
- NLDDIKRKFXEWBK-AWEZNQCLSA-N
- SMILES
- C(C1=CC=C(O)C(OC)=C1)CC(=O)C[C@@H](O)CCCCC
- LogP
- 2.485 (est)
- CAS Datenbank
- 23513-14-6(CAS DataBase Reference)
- NIST chemische Informationen
- Gingerol(23513-14-6)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher |
Xn |
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R-Sätze: |
22-36/37/38 |
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S-Sätze: |
26-36/37 |
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RIDADR |
UN 2811 6.1 / PGIII |
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WGK Germany |
3 |
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RTECS-Nr. |
HE0757000 |
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HS Code |
29145090 |
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Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
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Sicherheit |
P261 |
Einatmen von Staub vermeiden. |
P264 |
Nach Gebrauch gründlich waschen. |
P264 |
Nach Gebrauch gründlich waschen. |
P271 |
Nur im Freien oder in gut belüfteten Räumen verwenden. |
P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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6-Gingerol Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Light yellow ceraceous solid
Verwenden
[6]-Gingerol has been used:
- to study its effects on transient receptor potential (TRP) channels
- to study its effects on experimental models of non-alcoholic steatohepatitis
- to determine its effects on microsomal prostaglandine E2 synthase 1 (mPGES-1), glycogen synthase kinase 3β (GSK-3β) and β-catenin pathway in A549 cell line
- to analyse the effects of 6-Shogaol (6-SG) on diabetic nephropathy (DN) in db/db mice
Definition
ChEBI:Gingerol is a beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger. It has a role as an antineoplastic agent and a plant metabolite. It is a beta-hydroxy ketone and a member of guaiacols.
Allgemeine Beschreibung
6-Gingerol is a naturally occurring plant phenoland an active pungent constituent found in the rhizome of ginger, which is known to possess anti-inflammatory, anti-tumor and antioxidant properties and can hence, serve as a potential candidate in the treatment of cancer.
Anticancer Research
6-Gingerol is a plant polyphenol and an active constituent of Zingiber officinale, whichshowed antioxidant, anti-inflammation, and antitumor properties. It has the capacityto inhibit NOS, TNF-α, and COX-2 enzymes which are regulated by NF-κB(Aggarwal and Shishodia 2004; Wang et al. 2012). It hinders the cell growth ofprostate, gastric, and breast cancer cells and suppresses the lung metastasis ofB16F10 melanoma. It exhibits antitumorigenic effect in human colorectal cancercells via upregulating NSAID-activated gene-1 (NAG-1) (Aggarwal et al. 2008). Italters ERK1/2/JNK/AP1 pathway and induces apoptosis in colon cancer cells in acaspase-dependent manner (Singh et al. 2016b). ROS levels were significantlyincreased in K562 and MOLT4 cells treated with gingerol, and apoptosis wasinduced in leukemia cells by mitochondrial pathway (Wang et al. 2012).
6-Gingerol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
6-Gingerol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 397)Lieferanten
23513-14-6()Verwandte Suche:
- (5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone
- (S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one
- (S)-8-Oxo-10-(3-methoxy-4-hydroxyphenyl)decane-6-ol
- 6-Gingerol ,98%
- 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-,
(5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone
- (5S)-[6]-Gingerol
- 1-(4'-HYDROXY-3'-METHOXYPHENYL)-5-HYDROXY-3-DECANONE
- 6-GINGEROL
- [6]-GINGEROL, ZINGIBER OFFICINALE
- (5s)-5-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)decan-3-one
- GINGEROL [6]
- (S)-5-HYDROXY-1-(4-HYDROXY-3-METHOXY-PHENYL-3-DECANONE
- 5-HYDROXY-1-(4'-HYDROXY-3'-METHOXYPHENYL)-3-DECANONE
- (s)-(+)-(6)gingerol
- (s)-(+)-3-decanon
- 6-Gingerol, froM Zingiber officinale
- (s)-(6)-gingerol
- (s)-3-decanon
- 6-Gingerol std.
- 6-GINGEROL, 98% HPLC
- 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)
- [6]-Gingerol>
- [6]-Gingerol Standard
- (+)-[6]-Gingerol
- 6-Gingerol USP/EP/BP
- 3-Decanone,5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-
- 6-Gingerol, 98%, from Zingiber officinale Rosc.
- [6]-Gingerol, Zingiber officinale - CAS 23513-14-6 - Calbiochem
- 6-Gingerol 23513-14-6
- GINGEROL
- Gingerols
- rac-(R*)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decane-3-one
- Gingerol (6-Gingerol)
- Pyrroloquinoline Impurity 5
- Green Tea Extract Catechin
- Ginger Extract Gingerol
- 23513-14-6
- C17H26O4
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Aromatic Phenols
- Natural Plant Extract
- The group of Ginerols
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- Elisa Kit-plant ELISA Kit
- 23513-14-6