NS 3694 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Cytochrome
c, which leaks from the mitochondrial intermembrane space into the cytosol, causes oligomerization of apoptotic protease-activating factor 1 (Apaf-1), forming a caspase activation complex known as the apoptosome. NS3694 is a cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation. It blocks cytochrome
c-induced caspase activation in HeLa cell cytosolic extracts with an IC
50 value of approximately 50 μM. NS3694 prevents the formation of apoptosomes, which prevents the association of procaspases with Apaf-1. It suppresses caspase activation and apoptosis in cells treated with either TNF-α or staurosporine . NS3694 is used to examine the role of apoptosome-mediated caspase activation in cell death.
Verwenden
NS3694 is a suppressor of the formation of apoptosome Apaf-1.
NS 3694 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte