(Pivaloyloxy)methyl-[2S-[2α,5α,6β(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylatmonohydrochlorid

26309-95-5

CAS-Nr.: 26309-95-5

Bezeichnung:: (Pivaloyloxy)methyl-[2S-[2α,5α,6β(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylatmonohydrochlorid

Englisch Name:: Pivampicillin Hydrochloride

Synonyma:: Devonium;Centurina;Alphacillin;Alphacilina;Sanguicillin;PIVAMPICILLINHYDROCHLORIDE;AMpicillin PivaloxyoxyMethyl Ester Hydrochloride;6β-((R)-2-amino-2-phenyl-acetylamino)-penicillanic acid 2,2-dimethyl-propionyloxymethyl ester;(pivaloyloxy)methyl [2S-[2alpha,5alpha,6beta(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate monohydrochloride;(pivaloyloxy)methyl [2S-[2alpha,5alpha,6beta(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate monohydrochloride

CBNumber:: CB4934172

Summenformel:: C22H30ClN3O6S

Molgewicht:: 500.0081

MOL-Datei:: 26309-95-5.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 12

(Pivaloyloxy)methyl-[2S-[2α,5α,6β(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylatmonohydrochlorid Eigenschaften

Schmelzpunkt:: 155-156° (decomp)

alpha: D20 +196° (c = 1 in water)

storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere

Löslichkeit: DMSO (Slightly), Water (Slightly, Sonicated)

pka: pKa ~7.0(at 25℃)

Aggregatzustand: Solid

Farbe: White

Sicherheit

Toxizität	LD50 in mice, rats (g/kg): 3.34, 5.00 orally; 3.60, 4.50 s.c. (von Daehne)

(Pivaloyloxy)methyl-[2S-[2α,5α,6β(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylatmonohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Semi-synthetic antibiotic related to Penicillin (P223500). Antibacterial.

Kontakt-Allergie

Pivampicillin is a prodrug of ampicillin. It caused sensitization in 56 workers at a penicillin factory. Pivampicillin and pivmecillinam were responsible for contact dermatitis in pharmaceutical production workers. Ampicillin, mecillinam or amdinocillin, penicillin V and penicillin G were also implicated in cross-reactions.

Sicherheitsprofil

Moderately toxic by ingestion andsubcutaneous routes. When heated todecomposition it emits very toxic fumes of NOx, SOx, andHCl.

(Pivaloyloxy)methyl-[2S-[2α,5α,6β(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylatmonohydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Wasserstoff Chlormethylpivalat

Downstream Produkte

(Pivaloyloxy)methyl-[2S-[2α,5α,6β(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylatmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 12)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94717	76
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	sales@rrkchem.com	China	56068	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44843	58
Guangzhou Austine Biotechnology Co., LTD	17727342298	2781109436@qq.com	China	2004	58
United States Biological	--	sales@advtechind.com	United States	6106	58

(pivaloyloxy)methyl [2S-[2alpha,5alpha,6beta(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate monohydrochloride
PIVAMPICILLINHYDROCHLORIDE
(2S,5R,6R)-6-[[(2R)-2-AMino-2-phenylacetyl]aMino]-3,3-diMethyl-7-oxo-4-thia- 1-azabicyclo[3.2.0]heptane-2-carboxylic Acid (2,2-DiMethyl-1-oxopropoxy)Methyl Ester Hydrochloride
Alphacilina
Alphacillin
AMpicillin PivaloxyoxyMethyl Ester Hydrochloride
6β-((R)-2-amino-2-phenyl-acetylamino)-penicillanic acid 2,2-dimethyl-propionyloxymethyl ester
Centurina
Devonium
Sanguicillin
(pivaloyloxy)methyl [2S-[2alpha,5alpha,6beta(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate monohydrochloride
26309-95-5
C22H30ClN3O6S
C22H29N3O6SClH
Sulfur & Selenium Compounds
Chiral Reagents
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals