tirilazad

tirilazad Struktur
110101-67-2
CAS-Nr.
110101-67-2
Englisch Name:
tirilazad
Synonyma:
U-74006F
CBNumber:
CB51311375
Summenformel:
C39H56N6O5S
Molgewicht:
720.97
MOL-Datei:
110101-67-2.mol

tirilazad Eigenschaften

Sicherheit

tirilazad Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Tirilazad mesylate, a novel 21 -aminosteroid derivative, has been marketed in Austria for the intravenous treatment of subarachnoid hemorrhage (SAH) in male patients. Studies have indicated involvement of lipid peroxidation and/or lipid hydrolysis in the genesis of SAH-initiated microvascular damage and prolonged vasospasm of the large cerebral vessels. Tirilazad mesylate is a highly lipophilic compound that localizes to the cell membrane. It is a potent inhibitor of lipid peroxidation induced by oxygen free radicals, purely through a mechanism similar to vitamin E by scavenging lipid peroxyl radicals, and is a stabilizer of biological membranes. Tirilazad mesylate has been demonstrated to have a positive effect in reducing symptomatic vasospasm, cerebral infarction, and neurological dysfunction. Clinically, it is reportedly effective in reducing mortality in male SAH patients relative to the control group. The title compound is also reportedly in clinical trials for ischemic stroke, spinal cord injury, and for non-systemic ocular applications. Little or no behavioral and physiological side effects have been reported.

Originator

Pharmacia & Upjohn (Sweden/U.S.A.)

Trademarks

Freedox

tirilazad Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


tirilazad Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 4)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354
support@targetmol.com United States 19973 58
Jinan ponder chemical co. LTD 0531-0000
thinklifescience@163.com China 19690 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 24017 58

  • U-74006F
  • 110101-67-2
Copyright 2019 © ChemicalBook. All rights reserved