ARZOXIFENE

182133-25-1

CAS-Nr.: 182133-25-1

Englisch Name:: ARZOXIFENE

Synonyma:: SERMIII;ARZOXIFENE;2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol;2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]benzo[b]thiophene-6-ol;Benzo[b]thiophene-6-ol, 2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-;3-[(4-{[2-(hexahydropyridin-1-yl)ethyl]oxy}phenyl)oxy]-2-(4-methoxyphenyl)benzo[b]thiophen-6-ol

CBNumber:: CB52451290

Summenformel:: C28H29NO4S

Molgewicht:: 475.6

MOL-Datei:: 182133-25-1.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 21

ARZOXIFENE Eigenschaften

Schmelzpunkt:: 174-176°

Siedepunkt:: 656.4±55.0 °C(Predicted)

Dichte: 1.234

pka: 9.20±0.40(Predicted)

Sicherheit

ARZOXIFENE Chemische Eigenschaften,Einsatz,Produktion Methoden

Clinical Use

Arzoxifene is a third-generation SERM currently in Phase III clinical trials for the treatm ent of ER-positive recurrent/metastatic breast cancer. Similar to raloxifene, it is an ER antagonist in both breast and uterine tissues and an ER agonist on bone and the cardiovascular system. Arzoxifene is able to both preserve and build bone mineral density, which makes it a viable candidate for the treatment of osteoporosis. Ample evidence from early clinical trials indicates that arzoxifene also can be utilized as a chemopreventive agent against breast cancer.

Nebenwirkungen

Adverse effects include hot flashes (major) and headache, nausea, vomiting, and constipation (minor).

ARZOXIFENE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ARZOXIFENE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 21)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Hangzhou Sage Chemical Co., Ltd.	+86057186818502 13588463833	info@sagechem.com	China	10269	58
Beijing Yisiyan Technology Research Center	010-56645598 13366904824	bjkaida@163.com	China	1616	59
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12338	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	sales@rrkchem.com	China	56070	58
Beijing Fuchen Technology Co., Ltd	15652759959	623245911@qq.com	China	462	58
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	czbjpharma@126.com	China	18488	58

ARZOXIFENE
2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]benzo[b]thiophene-6-ol
Benzo[b]thiophene-6-ol, 2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-
2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol
3-[(4-{[2-(hexahydropyridin-1-yl)ethyl]oxy}phenyl)oxy]-2-(4-methoxyphenyl)benzo[b]thiophen-6-ol
SERMIII
182133-25-1