7,8-Dihydroxy-2-phenyl-4-benzopyron
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- CAS-Nr.
- 38183-03-8
- Bezeichnung:
- 7,8-Dihydroxy-2-phenyl-4-benzopyron
- Englisch Name:
- 7,8-Dihydroxyflavone
- Synonyma:
- 7,8-DHF;7,8-Dihydroxyflavone hydrate;7,8-dihydroxy-2-phenyl-4-benzopyrone;7,8-DIHYDROXY;7,8-Di-OH flavone;8-Dihydroxyflavone;TIMTEC-BB SBB000930;7,8-DIHYDROXYFLAVONE;DIHYDROXYFLAVONE, 7,8-;7,8-dihydroxy Flavones
- CBNumber:
- CB5478886
- Summenformel:
- C15H10O4
- Molgewicht:
- 254.24
- MOL-Datei:
- 38183-03-8.mol
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7,8-Dihydroxy-2-phenyl-4-benzopyron Eigenschaften
- Schmelzpunkt:
- 243-246°C
- Siedepunkt:
- 494.4±45.0 °C(Predicted)
- Dichte
- 1.443±0.06 g/cm3(Predicted)
- FEMA
- 4830 | 7,8-DIHYDROXYFLAVONE
- storage temp.
- Inert atmosphere,Room Temperature
- Löslichkeit
- DMSO: soluble24mg/mL
- Aggregatzustand
- solid
- pka
- 6.86±0.40(Predicted)
- Farbe
- Yellow or tan
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.
- InChI
- InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
- InChIKey
- COCYGNDCWFKTMF-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=CC=C2)OC2=C(O)C(O)=CC=C2C(=O)C=1
- LogP
- 2.760 (est)
- CAS Datenbank
- 38183-03-8(CAS DataBase Reference)
7,8-Dihydroxy-2-phenyl-4-benzopyron Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
7,8-Dihydroxyflavone(7,8-DHF) is a naturally occurring flavone found in the tree Godmania aesculifolia. It is a selective tyrosine kinase receptor B(TrkB) agonist that has neurotrophic effects in various neurological diseases such as stroke and Parkinson's disease. 7,8-Dihydroxyflavone binds to the TrkB receptors in a similar way to BDNF, or brain derived neurotrophic factor. When the TrkB receptor is activated, neuroprotective and neurogenetive effects occur in neurons, which tend to affect the dendrites. Dendrites are what reach out from the neurons into the synapse to participate in signaling with other neurons. 7,8-DHF has been shown to promote the growth of these dendrites, and to help restore communication between neurons in animal models.
Chemische Eigenschaften
White crystalline powder or Yellow Solid, soluble in methanol, ethanol, DMSO and other organic solvents, from the dried root of Pulsatilla chinensis (Bge.) Regel.
Verwenden
7,8-Dihydroxyflavone is disubstituted flavone that acts as a small-molecule TrkB agonist. 7,8-Dihydroxyflavone has been shown to reverse memory deficits and BACE1 elevation in a mouse model of Alzheimer''s disease. 7,8-Dihydroxyflavone may also provide a therapeutic option in the treatment of other neorological disorders such as Rett syndrome and PTSD. It has recently been shown to counteract the inhibition of NMDA receptor caused by lead poisoning and confer protective effects in live rats.
Biologische Aktivität
7,8-Dihydroxyflavone (7,8-DHF) is a monophenolic flavone with diverse effects. It acts as an agonist of the neurotrophic tyrosine kinase receptor TrkB (Kd = 320 nM), protecting neurons that express TrkB from apoptosis. 7,8-DHF is neuroprotective in an animal model of Parkinson’s disease. It supports emotional learning in mice and reverses memory deficits in a mouse model of Alzheimer’s disease. It also improves motor function and extends survival in an animal model of Huntington’s disease. 7,8-DHF inhibits the cytochrome P450 aromatase (IC50 = 10 μM) and, in this way, alters estrogen metabolism. It also has antioxidant action that increases intracellular glutathione synthesis and scavenges reactive oxygen species.
7,8-Dihydroxy-2-phenyl-4-benzopyron Upstream-Materialien And Downstream Produkte
Upstream-Materialien
4H-1-Benzopyran-4-one, 2-phenyl-7,8-bis(phenylmethoxy)-
4H-1-Benzopyran-4-one, 7,8-bis(benzoyloxy)-2-phenyl-
Ethanone, 1-[2,3,4-tris(phenylmethoxy)phenyl]-
Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]-
7,8-DIMETHOXYFLAVONE
2'-HYDROXY-3',4'-DIMETHOXYACETOPHENONE
2',3',4'-Trihydroxyacetophenon
7-Hydroxy-2-phenyl-4-benzopyron
1,2,3-Trihydroxybenzol
Benzoesureanhydrid
Benzoylchlorid
Downstream Produkte
7,8-Dihydroxy-2-phenyl-4-benzopyron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 298)Lieferanten
38183-03-8(7,8-Dihydroxy-2-phenyl-4-benzopyron)Verwandte Suche:
- 7,8-DIHYDROXYFLAVONE
- DIHYDROXYFLAVONE, 7,8-(RG)
- 7,8-dihydroxy-2-phenyl-4h-1-benzopyran-4-on
- TIMTEC-BB SBB000930
- DIHYDROXYFLAVONE, 7,8-
- 7,8-Dihydroxy-2-phenyl-4H-chroMen-4-one
- 4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl-
- 2-Phenyl-7,8-dihydroxy-4H-1-benzopyran-4-one
- 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
- 7,8-dihydroxy-2-phenyl-chromen-4-one
- 7,8-dihydroxy-2-phenylchromen-4-one
- 7,8-dihydroxy-2-phenyl-chromone
- 6,7-dihydroxy-2-phenyl-4H-chromen-4-one
- 7,8-DIHYDROXY
- 7,8-dihydroxy Flavones, 7,8-DHF
- 7,8-dihydroxy-2-phenyl-1-benzopyran-4-one
- 8-Dihydroxyflavone
- 7,8-DIHYDROXYFLAVONE 7,8-DIHYDROXYFLAVONE
- 7,8-dihydroxyflavone (7,8-DHF)
- 7,8-DihydroxyflavoneHydrate>
- 7,8-dihydroxy Flavones
- 7,8-Di-OH flavone
- Flavone,7,8-dihydroxy- (6CI)
- 7,8-dihydroxy-2-phenyl-4-benzopyrone
- 7,8-Dihydroxyflavone hydrate
- 7,8-DHF
- 2-(Dimethylamino)ethyl methacrylate 2867-47-2
- 7,8-Dihydroxyflavone, ≥ 98.0%
- Acibenzolar Acid Impurity 16
- 38183-03-8
- C15H10O4xH2O
- Flavonoids
- Inhibitors
- Biochemistry
- Flavonoids
- Di-substituted Flavones
- pharmaceutical
- BPC
- plant extract
