7,8-Dihydroxyflavone
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7,8-Dihydroxyflavone 속성
- 녹는점
- 243-246°C
- 끓는 점
- 494.4±45.0 °C(Predicted)
- 밀도
- 1.443±0.06 g/cm3(Predicted)
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- DMSO: 가용성24mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 6.86±0.40(Predicted)
- 색상
- 노란색 또는 황갈색
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. 습기로부터 보호하십시오. DMSO 또는 에탄올 용액은 -20°C에서 최대 1주일 동안 보관할 수 있습니다.
- InChI
- InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
- InChIKey
- COCYGNDCWFKTMF-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=CC=C2)OC2=C(O)C(O)=CC=C2C(=O)C=1
- LogP
- 2.760 (est)
- CAS 데이터베이스
- 38183-03-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
7,8-Dihydroxyflavone C화학적 특성, 용도, 생산
개요
7,8-Dihydroxyflavone(7,8-DHF) is a naturally occurring flavone found in the tree Godmania aesculifolia. It is a selective tyrosine kinase receptor B(TrkB) agonist that has neurotrophic effects in various neurological diseases such as stroke and Parkinson's disease. 7,8-Dihydroxyflavone binds to the TrkB receptors in a similar way to BDNF, or brain derived neurotrophic factor. When the TrkB receptor is activated, neuroprotective and neurogenetive effects occur in neurons, which tend to affect the dendrites. Dendrites are what reach out from the neurons into the synapse to participate in signaling with other neurons. 7,8-DHF has been shown to promote the growth of these dendrites, and to help restore communication between neurons in animal models.화학적 성질
White crystalline powder or Yellow Solid, soluble in methanol, ethanol, DMSO and other organic solvents, from the dried root of Pulsatilla chinensis (Bge.) Regel.용도
7,8-Dihydroxyflavone is disubstituted flavone that acts as a small-molecule TrkB agonist. 7,8-Dihydroxyflavone has been shown to reverse memory deficits and BACE1 elevation in a mouse model of Alzheimer''s disease. 7,8-Dihydroxyflavone may also provide a therapeutic option in the treatment of other neorological disorders such as Rett syndrome and PTSD. It has recently been shown to counteract the inhibition of NMDA receptor caused by lead poisoning and confer protective effects in live rats.생물학적 활성
7,8-Dihydroxyflavone (7,8-DHF) is a monophenolic flavone with diverse effects. It acts as an agonist of the neurotrophic tyrosine kinase receptor TrkB (Kd = 320 nM), protecting neurons that express TrkB from apoptosis. 7,8-DHF is neuroprotective in an animal model of Parkinson’s disease. It supports emotional learning in mice and reverses memory deficits in a mouse model of Alzheimer’s disease. It also improves motor function and extends survival in an animal model of Huntington’s disease. 7,8-DHF inhibits the cytochrome P450 aromatase (IC50 = 10 μM) and, in this way, alters estrogen metabolism. It also has antioxidant action that increases intracellular glutathione synthesis and scavenges reactive oxygen species.7,8-Dihydroxyflavone 준비 용품 및 원자재
원자재
4H-1-Benzopyran-4-one, 2-phenyl-7,8-bis(phenylmethoxy)-
4H-1-Benzopyran-4-one, 7,8-bis(benzoyloxy)-2-phenyl-
Ethanone, 1-[2,3,4-tris(phenylmethoxy)phenyl]-
Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]-
7,8-디메톡시플라본
2'-HYDROXY-3',4'-DIMETHOXYACETOPHENONE
갈라세토페논
7-HYDROXYFLAVONE
피로갈롤
벤조 무수물
염화벤조일
준비 용품
7,8-Dihydroxyflavone 공급 업체
글로벌( 292)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 |
nutrabiotech@outlook.com | China | 300 | 58 |
Wuhan senwayer century chemical Co.,Ltd | +undefined-27-86652399 +undefined13627115097 |
market02@senwayer.com | China | 894 | 58 |
Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd | +86-02223869539 +86-15560057295 |
trade.kilopharma@foxmail.com | China | 27 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12450 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Shanghai Qyubiotech Co., Ltd. | +86-086-021-37596619 +8618019359838 |
info@qyubiotech.com | China | 300 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 |
Sara@xmwonderfulbio.com | China | 305 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 2989 | 58 |
Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 |
sales@chembj.net | China | 289 | 58 |
7,8-Dihydroxyflavone 관련 검색:
크리신 탄게레틴 플라본 바이칼린
11-a-Hydroxy canrenone methyl ester
(7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester
3',4',5',6,7,8-HEXAMETHOXY-5-HYDROXYFLAVONE
3',4',7,8-TETRAMETHOXYFLAVONE
3,7,3',4'-TETRAMETHYLGOSSYPETIN
7,8-Dihydroxyflavone
GOSSYPIN
3,7-Bis[(6-deoxy-α-L-mannopyranosyl)oxy]-4',5-dihydroxyflavone
3,6-DIHYDROXYFLAVONE
4',5-DIHYDROXYFLAVONE
3',4'-DIHYDROXYFLAVONE
3,4',6,7-Tetramethoxy-3',5-dihydroxyflavone
4',3-DIHYDROXYFLAVONE,3,4'-DIHYDROXYFLAVONE
3,2'-DIHYDROXYFLAVONE