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Dextromethorphan hydrobromide monohydrate

Dextromethorphan hydrobromide monohydrate Struktur
6700-34-1
CAS-Nr.
6700-34-1
Englisch Name:
Dextromethorphan hydrobromide monohydrate
Synonyma:
Dextromethorphan HBr monohydrate;DextroMethorphan hydrobroMide hydrate;dextromethorphansigmareference*standard;Dextromethorphan Hydrobromide dextrorotation;(9S,13S,14S)-3-METHOXY-17-METHYLMORPHINAN HYDROBROMIDE, D-3-METHOXY-N-METHYLMORPHINAN HYDROBROMIDE MONOHYDRATE;DMHM;Dextromethorphan hyd;DEXTROMETHORPHAN HBr IP;Morphinan,3-methoxy-17-methyl-;Dextromethorphani Hydrobromidum
CBNumber:
CB6131946
Summenformel:
C18H28BrNO2
Molgewicht:
370.33
MOL-Datei:
6700-34-1.mol

Dextromethorphan hydrobromide monohydrate Eigenschaften

Schmelzpunkt:
116-119°C
alpha 
[α]D25 +26～+30° (c=1.85, H2O)
Flammpunkt:
11 °C
storage temp. 
Store at RT
Löslichkeit
Sparingly soluble in water, freely soluble in ethanol (96 per cent).
Aggregatzustand
solid
Farbe
White to Off-White
PH
pH (10g/l, 25℃) : 5.2～6.5
BRN 
6453793
InChIKey
QYPSYPPSHXDFLV-UHFFFAOYSA-N
LogP
1.351 (est)
CAS Datenbank
6700-34-1(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher F,T
R-Sätze: 11-23/24/25-39/23/24/25
S-Sätze: 7-16-36/37-45
WGK Germany  3
HS Code  3822000002
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H411 Giftig für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 2
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P273 Freisetzung in die Umwelt vermeiden.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P391 Verschüttete Mengen aufnehmen.
P405 Unter Verschluss aufbewahren.

Dextromethorphan hydrobromide monohydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant. However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM). DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.

Chemische Eigenschaften

White Solid

Verwenden

An antitussive drug. Orally active synthetic morphine analog. Analgesic (narcotic). Racemethorphan and levomethorpham are controlled substances (opiates).

Biologische Aktivität

Non-competitive, low affinity NMDA receptor antagonist. Antitussive, anticonvulsive and neuroprotective agent.

Dextromethorphan hydrobromide monohydrate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

6700-34-1()Verwandte Suche:

Melibiose Dextromethorphan Hydrogenbromid 3-Methoxy-17-methyl-morphinan,(9 alpha, 13 alpha, 14 alpha)-hydrobromid
  • DMHM
  • (9α,13α,14α)-3-Methoxy-17-MethylMorphinan HydrobroMide Hydrate
  • 3-Methoxy-17-Methyl-9α,13α,14α-Morphinan HydrobroMide Hydrate
  • d-3-Methoxy-N-MethylMorphinan HydrobroMide Monohydrate
  • DextroMethorphan hydrobroMide:Monohydrat
  • Morphinan,3-Methoxy-17-Methyl-, hydrobroMide, hydrate (1:1:1), (9a,13a,14a)-
  • D-3-METHOXY-N-METHYLMORPHINAN HYDROBROMIDE
  • DEXTROMETHORPHAN HYDROBROMIDE MONOHYDRATE
  • DEXTROMETHORPHAN HYDROBROMIDE, PH EUR
  • DEXTROMETHORPHAN HYDROBROMIDE*MONOHYDRAT E USP
  • D-Methorphan hydrobromide monohydrate
  • Morphinan, 3-methoxy-17-methyl-, hydrobromide, monohydrate, (9.alpha.,13.alpha.,14.alpha.)-
  • Dextromethorphan hydrobromicum, (9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide
  • Dextromethorphan monohydrate hydrobromide
  • Dextromethorphan monohydrate hydrobromide, (9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide
  • (9α,13α,14α)-3-Methoxy-17-methylmorphinanhydrobromide
  • Dextromethorphan hydrobromide monohydrate,(9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide, Dextromethorphan hydrobromicum
  • Dextromethorphan hydrobromide monohydrate,(9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide, d-3-Methoxy-N-methylmorphinan hydrobromide monohydrate, Dextromethorphan hydrobromide monohydrate
  • Dextromethorphan Hydrobromide (500 mg) Certified Reference Material (CRM)
  • Dextromethorphan Hydrobromide (500 mg)
  • Dextromethorphan hyd
  • DextroMethorphan HydrobroMide (Certified Reference Material (CRM))
  • DextroMethorphan HydrobroMide, Monohydrate, USP, EP
  • (+)-3-Methoxy-N-MethylMorphinan HydrobroMide Monohydrate
  • Morphinan,3-methoxy-17-methyl-
  • Dextromethorphani Hydrobromidum
  • High quality pure dextromethorphan hydrochloride powder
  • Dextromethorphan hydrobromide monohydrate USP/EP/BP
  • Dextromethorphan Hydrobromide MonohydrateQ: What is Dextromethorphan Hydrobromide Monohydrate Q: What is the CAS Number of Dextromethorphan Hydrobromide Monohydrate Q: What is the storage condition of Dextromethorphan Hydrobromide Monohydrate Q: What are the applications of Dextromethorphan Hydrobromide Monohydrate
  • Dextromethorphan Hydrobromide (1181007)
  • Dextromethorphan Hydrobromide dextrorotation
  • dextromethorphansigmareference*standard
  • DextroMethorphan hydrobroMide hydrate
  • Dextromethorphan HBr monohydrate
  • (9S,13S,14S)-3-METHOXY-17-METHYLMORPHINAN HYDROBROMIDE, D-3-METHOXY-N-METHYLMORPHINAN HYDROBROMIDE MONOHYDRATE
  • Pharmaceutical Dextromethorphan Hydrobromide Monohydrate
  • DEXTROMETHORPHAN HBr IP
  • (4bS,8aS,9S)-3-methoxy-11-methyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene hydrobromide hydrate
  • Dexmesophane hydrobromide monohydrate
  • Dextromethorphan hydrobromide monohydratec
  • 6700-34-1
  • C18H28BrNO2
  • C18H25NOHBrH2O
  • 37032
  • C18H30BrNO3
  • Allosteric antagonist at NMDA-controlled ion channels; antagonist at voltage-dependent channels
  • Complex Molecules
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Other APIs
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