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thielavin A

thielavin A Struktur
71950-66-8
CAS-Nr.
71950-66-8
Englisch Name:
thielavin A
Synonyma:
thielavin A;4-[(2,4-Dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethylbenzoic acid 4-carboxy-3-hydroxy-2,5,6-trimethylphenyl ester;Benzoic acid, 4-[(2,4-dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethyl-, 4-carboxy-3-hydroxy-2,5,6-trimethylphenyl ester
CBNumber:
CB61386873
Summenformel:
C29H30O10
Molgewicht:
538.54
MOL-Datei:
71950-66-8.mol
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thielavin A Eigenschaften

Schmelzpunkt:
235-236 °C
Siedepunkt:
850.0±65.0 °C(Predicted)
Dichte
1.371±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
DMF: souble; DMSO: souble; Ethanol: soluble
Aggregatzustand
White to off-white powder.
pka
2.82±0.28(Predicted)

Sicherheit

thielavin A Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H2 (PGH2; ) and the conversion of PGH2 to PGE2 (; IC50s = 10 and 40 μM, respectively). Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 μM; Ki = 27.8 μM).

Verwenden

The fungal metabolite, thielavin A, and its relatives are glucose-6-phosphatase inhibitors. The three benzoic acid units are essential for inhibition. Thielavin A was originally isolated as a inhibitor of prostaglandin biosynthesis. The closely related thielavin B is a telomerase and cell wall transglycosylation inhibitor.

thielavin A Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

thielavin A Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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71950-66-8()Verwandte Suche:

4-[(4-Methoxy-6-methylsalicyloyl)oxy]-6-methylsalicylsure
  • thielavin A
  • 4-[(2,4-Dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethylbenzoic acid 4-carboxy-3-hydroxy-2,5,6-trimethylphenyl ester
  • Benzoic acid, 4-[(2,4-dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethyl-, 4-carboxy-3-hydroxy-2,5,6-trimethylphenyl ester
  • 71950-66-8
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