1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Mechanism of action
Although βCCE and other β-carbolines are not endogenous BZR
ligands (vide supra) and are not currently approved for clinical use, they are used to characterize different
GABAA/BZR subtypes (based on a and g subunit composition) and function (e.g., the partial agonist abecarnil)
toward the discovery of anxioselective drugs. In this regard, the β-carboline ring system is planar in comparison
to the boat conformation of the 1,4-benzodiazepines; thus, β-carbolines
have been useful to extend structure–activity relationship information for the agonist, antagonist, and inverse
agonist pharmacophores of the various GABAA/BZR subtypes.
Clinical Use
Several β-carbolines have approximately 10-fold higher affinity for the BZR when compared to diazepam. The ethyl
ester of β-carboline-3-carboxylic acid (βCCE), identified in human urine extracts as an artifact of the extraction
procedure, has very high affinity for the BZR.
1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte