GQ-16 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Full activation of peroxisome proliferator-
activated receptor γ (PPARγ),
e.g., using thiazolidinediones, effectively treats insulin resistance and type 2 diabetes but also commonly promotes weight gain, hyperphagia, and edema. GQ-
16 is a partial agonist for PPARγ (K
i = 160 nM) which induces adipogenesis significantly less than the full activator rosiglitazone. Like rosiglitazone, GQ-
16 reverses high fat diet-
mediated impairments in insulin signaling. However, GQ-
16 does not induce weight gain, hyperphagia, or edema. GQ-
16 does not activate PPARα, PPARβ/δ, or RXRα.
GQ-16 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
