EC 3.1.1.1

EC 3.1.1.1 Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.

Verwenden

Carboxylesterase 1 isoform c human has been used as a reference standard in carboxylesterase activity from the mussel for comparison of substrate specificity and inhibition studies. It has also been used as a commercial recombinant protein for the methodological validation of environmental chemical-based inhibition studies.

Allgemeine Beschreibung

Carboxylesterase 1 is a member of a large multigene carboxylesterase family. These enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds.

Biochem/physiol Actions

Carboxylesterase enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. Carboxylesterase 1 (CE1) catalyzes the formation of cholesteryl esters from cholesterol and fatty acids. Through a transesterification reaction, CE1 also mediates the generation of fatty acid ethyl esters (FAEEs). It also hydrolyzes aromatic and aliphatic esters with preference to small alcohol groups and bulky acyl groups. CE1 metabolizes drug esters and amides carbamates. It participates in the detoxification of environmental toxicants and carcinogens and is useful in pharmacokinetic studies for evaluating pro-drugs.

EC 3.1.1.1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

EC 3.1.1.1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80

9013-79-0()Verwandte Suche:

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• LIPASE CA
• Carboxylesterase 1 isoform b human
• Carboxylesterase 1 human
• Carboxylesterase 1 isoform c human
• CARBOXYLESTERASE, IMMOBILIZED
• CARBOXYLIC-ESTER HYDROLASE
• CARBOXYL ESTERASE
• EC 3.1.1.1
• HLE
• ESTERASE
• ESTERASE BS1
• ESTERASE BS2
• ESTERASE BS2-CLEA
• ESTERASE BS3
• ESTERASE BS4
• ESTERASE, FRACTION 1 (PIG LIVER)
• ESTERASE, FRACTION 2 (PIG LIVER)
• ESTERASE, IMMOBILIZED ON EUPERGIT(R) C
• ESTERASE, IMMOBILIZED ON OXIRAN ACRYLIC BEADS
• ESTERASE ISOENZYME 1
• ESTERASE PF1
• ESTERASE PF2
• ESTERASE (PIG LIVER)
• ESTERASE PL
• ESTERASE RO
• ESTERASE SD
• ESTERASE SOLUTION PORCINE LIVER
• ESTERASE TL
• PIG LIVER ESTERASE, IMMOBILIZED ON EUPERGIT(R) C
• PLE ON EUPERGIT(R) C
• PLE
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