Cdk1/2 Inhibitor III

443798-47-8

CAS-Nr.: 443798-47-8

Englisch Name:: Cdk1/2 Inhibitor III

Synonyma:: K00546;K00546 (K 00546);1H-1,2,4-Triazole-1-carbothioamide, 5-amino-3-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-

CBNumber:: CB64666985

Summenformel:: C15H13F2N7O2S2

Molgewicht:: 425.44

MOL-Datei:: 443798-47-8.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 12

Cdk1/2 Inhibitor III Eigenschaften

Siedepunkt:: 649.1±65.0 °C(Predicted)

Dichte: 1.72±0.1 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: ≤10mg/ml in DMSO

Aggregatzustand: solid

pka: 6.61±0.70(Predicted)

Farbe: White to off-white

Sicherheit

Cdk1/2 Inhibitor III Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/2 Inhibitor III is a cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC₅₀s = 0.6 and 0.5 nM, respectively). It less potently inhibits CDC2-like kinases 1 and 3, VEGFR2, and GSK-3β (IC₅₀s = 8.9, 29, 32, and 140 nM, respectively) and is without effect against a panel of other kinases. Cdk1/2 Inhibitor III blocks the growth of several cancer cell lines (IC₅₀ values range from 20 to 92 nM).

Verwenden

Cdk1/2 Inhibitor III is a cyclin-?dependent kinase (CDK) inhibitor. Cdk1 and Cdk2 performs inhibitory activities, and in vitro cellular proliferation in various human tumor cells.

Cdk1/2 Inhibitor III Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Cdk1/2 Inhibitor III Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 12)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52925	58
TargetMol Chemicals Inc.	+8613564774135	zijue.cai@tsbiochem.com	United States	19863	58
BOC Sciences	16314854226	info@bocsci.com	United States	9923	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11217	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8140	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24648	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9272	58
ApexBio Technology	--	sales@apexbt.com	United States	6251	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	cindy.huang@synzest.com	China	12005	58

K00546
1H-1,2,4-Triazole-1-carbothioamide, 5-amino-3-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-
K00546 (K 00546)
443798-47-8