Tomatidine hydrochloride

6192-62-7

CAS-Nr.: 6192-62-7

Englisch Name:: Tomatidine hydrochloride

Synonyma:: TOMATIDINE HCL;TOMATIDINE HCL(RG);TOMATIDINE HYDROCHLORIDE;ToMatidin Hydrochloride, >85%;Tomatidine Hydrochloride, >5alpha-Tomatidan-3beta-ol HCl;Tomatidine, Hydrochloride, >85%;5α-Tomatidan-3β-ol hydrochloride;SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL;3β-Hydroxy-5α-tomatidane hydrochloride

CBNumber:: CB6774105

Summenformel:: C27H46ClNO2

Molgewicht:: 452.11

MOL-Datei:: 6192-62-7.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 109

Tomatidine hydrochloride Eigenschaften

Schmelzpunkt:: 281-284°C (dec.)

storage temp.: 2-8°C

Löslichkeit: Methanol (Slightly)

Aggregatzustand: Off-white solid

Farbe: White to Off-White

BRN: 3920740

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

S-Sätze:	22-24/25
WGK Germany	3

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501

Sicherheit

P264	Nach Gebrauch gründlich waschen.
P264	Nach Gebrauch gründlich waschen.
P270	Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312	BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501	Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Tomatidine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

Off-White Solid

Verwenden

Tomatidine hydrochloride is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine.Tomatidine protects against muscle atrophy and boosting muscle growth (see also Ursolic Acid).

Biologische Aktivität

Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM. It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 μg/ml, respectively). It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice. Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.

Mode of action

Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.

Tomatidine hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Tomatidine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 109)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Chengdu Greenpure Biopharma CO.,Ltd	+8618283602253	jancyzheng@gcgreenpure.com	China	952	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29826	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	12330	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
Aktin Chemicals, Inc.	028-85159085	info@aktinchem.com	CHINA	1025	58
Wuhan Nutra Biotechnology Co.,Ltd	+8617786394783	nutrabiotech@outlook.com	China	300	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9626	58

6192-62-7()Verwandte Suche:

psi,psi-Carotin Hyoscyamin beta-D-Galactopyranosid, (3 beta,5 alpha, 22 beta, 25S)-spirosolan-3-yl-O-beta-D-glucopyranosyl-(1=> 2)-O-(beta-D-xylopyranosyl-(1=> 3))-O-beta-D-glucopyranosyl-(1=> 4)- 5-α-Cholestan-3-β-ol Tomatidin Octadecylaminhydrochlorid N, alpha-Dimethylcyclopentanetha-namin-hydrochlorid

3BETA-HYDROXY-5ALPHA-TOMATIDANE HYDROCHLORIDE
5ALPHA-TOMATIDAN-3BETA-OL HYDROCHLORIDE
TOMATIDINE HCL
TOMATIDINE HYDROCHLORIDE
SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL
(3beta,5alpha,22beta,25S)-Spirosolan-3-ol hydrochloride
TOMATIDINE HCL(RG)
Tomatidine, Hydrochloride, >85%
ToMatidin Hydrochloride, >85%
3β-Hydroxy-5α-tomatidane hydrochloride, 5α-Tomatidan-3β-ol hydrochloride
(3β,5α,22β,25S)-Spirosolan-3-ol Hydrochloride
(3beta,5alpha,22beta,25S)-Spirosolan-3-ol hydrochloride (1:1)
3β-Hydroxy-5α-tomatidane hydrochloride
5α-Tomatidan-3β-ol hydrochloride
Tomatidine, HCl - CAS 6192-62-7 - Calbiochem
Tomatidine Hydrochloride, >
5alpha-Tomatidan-3beta-ol HCl
6192-62-7
C27H46ClNO2
C27H45NO2HCl
Lipid signaling
Intermediates & Fine Chemicals
Pharmaceuticals
Steroids