Tomatidine hydrochloride
- CAS No.
- 6192-62-7
- Chemical Name:
- Tomatidine hydrochloride
- Synonyms
- TOMATIDINE HCL;TOMATIDINE HCL(RG);TOMATIDINE HYDROCHLORIDE;ToMatidin Hydrochloride, >85%;Tomatidine Hydrochloride, >5alpha-Tomatidan-3beta-ol HCl;Tomatidine, Hydrochloride, >85%;5α-Tomatidan-3β-ol hydrochloride;SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL;3β-Hydroxy-5α-tomatidane hydrochloride
- CBNumber:
- CB6774105
- Molecular Formula:
- C27H46ClNO2
- Molecular Weight:
- 452.11
- MDL Number:
- MFCD11521518
- MOL File:
- 6192-62-7.mol
- MSDS File:
- SDS
Melting point | 281-284°C (dec.) |
---|---|
storage temp. | 2-8°C |
solubility | Methanol (Slightly) |
form | Off-white solid |
color | White to Off-White |
BRN | 3920740 |
FDA UNII | ENY5VJU5UB |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
Safety Statements | 22-24/25 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
Tomatidine hydrochloride price More Price(26)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | T2909 | Tomatidine hydrochloride ≥85% | 6192-62-7 | 25mg | $75.2 | 2024-03-01 | Buy |
Sigma-Aldrich | PHL80003 | Tomatidine hydrochloride phyproof? Reference Substance | 6192-62-7 | 20MG | $328 | 2023-01-07 | Buy |
Sigma-Aldrich | 614350 | Tomatidine, HCl | 6192-62-7 | 25mg | $96.4 | 2023-01-07 | Buy |
Cayman Chemical | 16938 | Tomatidine (hydrochloride) ≥90% | 6192-62-7 | 10mg | $36 | 2024-03-01 | Buy |
Cayman Chemical | 16938 | Tomatidine (hydrochloride) ≥90% | 6192-62-7 | 25mg | $66 | 2024-03-01 | Buy |
Tomatidine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
Tomatidine hydrochloride is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine.Tomatidine protects against muscle atrophy and boosting muscle growth (see also Ursolic Acid).
Biological Activity
Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM. It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 μg/ml, respectively). It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice. Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.
Mode of action
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.
Tomatidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3777 | 58 |
Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 953 | 58 |
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 11006 | 58 |
Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | nutrabiotech@outlook.com | China | 300 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from Tomatidine hydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
|
2023-02-24 | Tomatidine hydrochloride
6192-62-7
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
|
2023-02-24 | Tomatidine hydrochloride
6192-62-7
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
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2020-01-19 | TOMATIDINE HYDROCHLORIDE
6192-62-7
|
US $3.00 / KG | 1KG | 98% | 1kg,5kg,50kg | Career Henan Chemical Co |
-
- Tomatidine hydrochloride
6192-62-7
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Tomatidine hydrochloride
6192-62-7
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- TOMATIDINE HYDROCHLORIDE
6192-62-7
- US $3.00 / KG
- 98%
- Career Henan Chemical Co
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