CGP 57380
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- CAS-Nr.
- 522629-08-9
- Englisch Name:
- CGP 57380
- Synonyma:
- P 57380;CS-1420;CGP 57380;C P 57380;MNK1 Inhibitor;CGP 57380 ，S7421;CGP57380; CGP-57380;CGP 57380, MNK inhibitor;CGP 57380, 10 mM in DMSO;MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem
- CBNumber:
- CB6972321
- Summenformel:
- C11H9FN6
- Molgewicht:
- 244.23
- MOL-Datei:
- 522629-08-9.mol
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CGP 57380 Eigenschaften
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: soluble10mg/mL, clear
- Aggregatzustand
- powder
- Farbe
- white to beige
- InChI
- 1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
- InChIKey
- UQPMANVRZYYQMD-UHFFFAOYSA-N
- SMILES
- Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| HS Code |
2933599590 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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CGP 57380 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
CGP 57380 has been used:
- as a mitogen-activated protein kinase-interacting kinase 1 (MNK1) inhibitor to investigate the role of Mnk1 on eukaryotic translation initiation factor 4F (eIF4F) assembly and Newcastle disease virus (NDV) replication in HeLa cells
- as an MNK1 inhibitor to block eIF4 complex to evaluate the contribution of interferon (IFN-γ) translation during m157- transgenic (Tg) stimulation
- as a β-catenin nuclear translocation inhibitor to analyze its effects on cytoplasmic and nuclear fractions of cells
Biologische Aktivität
Inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC 50 = 2.2 μ M) that displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases. Blocks phosphorylation of eIF4E in cellular assays (IC 50 = 3 μ M) and inhibits LPS-induced TNF α expression in macrophages.
Biochem/physiol Actions
CGP 57380 is a β-catenin nuclear translocation inhibitor, which prevents the proliferation of severalcancers. It enhances radiation-induced apoptosis in nasopharyngeal carcinoma (NPC). CGP 57380 upregulates β-catenin in the cytoplasm and inhibits epithelial-mesenchymal transition (EMT).
CGP 57380 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CGP 57380 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 115)Lieferanten
522629-08-9()Verwandte Suche:
- CGP 57380
- CGP57380, N3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine
- MNK1 Inhibitor
- N3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
- CGP57380; CGP-57380
- CS-1420
- MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem
- P 57380
- 1H-Pyrazolo[3,4-d]pyrimidine-3,4-diamine, N3-(4-fluorophenyl)-
- 3-N-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
- CGP-57380,CGP 57380,Mitogen activated protein kinase interacting kinase,Inhibitor,MAPK interacting kinase,inhibit,CGP57380,MNK,Apoptosis,MAP kinase interacting kinase
- C P 57380
- CGP 57380, MNK inhibitor
- CGP 57380, 10 mM in DMSO
- CGP 57380 ，S7421
- 522629-08-9
- C11H9FN6
- Inhibitors
