TETANUS TOXIN C FRAGMENT
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- CAS-Nr.
- Englisch Name:
- TETANUS TOXIN C FRAGMENT
- Synonyma:
- TTC;RTTC;TSTX-K-ALPHA-TTC;TETANUS TOXIN C FRAGMENT;TETANUS TOXIN C-FRAGMENT RECOMBINANT;TETANUS TOXIN, C-FRAGMENT, CLOSTRIDIUM TETANI;Tetanus toxin C fragment from Clostridium tetani
- CBNumber:
- CB7252844
- Summenformel:
- Molgewicht:
- 0
- MOL-Datei:
- Mol file
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TETANUS TOXIN C FRAGMENT Eigenschaften
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
T+ |
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| R-Sätze: |
26/27/28 |
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| S-Sätze: |
45-36/37-28 |
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| RIDADR |
UN 3462 6.1 / PGII |
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| WGK Germany |
1 |
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| RTECS-Nr. |
XW5807000 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H311 |
Giftig bei Hautkontakt. |
Akute Toxizität dermal |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P280, P302+P352, P312, P322, P361,P363, P405, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
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TETANUS TOXIN C FRAGMENT Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Verwenden
The C terminal binding portion of tetanus toxin is not toxic but is taken up by pre-synaptic nerve terminals and exhibits trans-synaptic retrograde transport in central neurons similar to that of tetanus toxin. It is used to map neuronal connections and to target proteins to neurons.
Allgemeine Beschreibung
Tetanus toxin C fragment (TTC) is a non-toxic peptide, which is transported from peripheral axons into spinal motoneurons. It provides protection for motoneurons (MN) in the spinal cord
in vivo. TTC regulates membrane binding, internalization and retrograde transport within MN. It initiates neurotrophin-regulated signaling pathways in a Trk receptor-dependent manner. TTC has neuroprotective property in primary cerebellar granule cell culture.
Biochem/physiol Actions
Tetanus toxin is a neurotoxin that comprises of a heavy and a light chain linked by disulfide bridges. This neurotoxin enters the cytoplasm and releases the light chain component that subsequently inhibits the release of neurotransmitters2. Studies have reported that the fragment C of tetanus toxin retains most of the determinants that interact with thyroid membranes, gangliosides and neural membranes3.
TETANUS TOXIN C FRAGMENT Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
TETANUS TOXIN C FRAGMENT Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 15)Lieferanten
- TSTX-K-ALPHA-TTC
- TETANUS TOXIN C FRAGMENT
- TETANUS TOXIN, C-FRAGMENT, CLOSTRIDIUM TETANI
- TETANUS TOXIN C-FRAGMENT RECOMBINANT
- RTTC
- Tetanus toxin C fragment from Clostridium tetani
- TTC
- 299-96-4
