ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT

ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Verwenden

4-Androsten-11β-ol-3,17-dione has been used in platelet aggregation.

Allgemeine Beschreibung

Ala-Tyr-Pro-Gly-Lys-Phe-NH₂ (AYPGKF- NH₂) is a selective, specific proteinase-activated receptor 4 (PAR4) agonist peptide. PAR4 is a G-protein-coupled receptor that is expressed on the surface of human platelets and is involved in the thrombin signaling pathway. Cleavage of PAR4 by the protease thrombin stimulates the receptor and results in signaling of platelet aggregation.

Biochem/physiol Actions

AYPGK is a ligand for the PAR4 receptor; binding results in activation of PAR4. AYPGK stimulates platelet aggregation in vitro (EC50 =15 μM) via PAR4. In human platelets treated with the PAR4 agonist, AYPGKF stimulates the production of thromboxane, a potent agent for platelet-aggregation. Additionally, AYPGKF mediates the thrombin-induced release of endostatin from rat platelets.

ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Riedel-de Haen AG	--		United States	6825	87
SIGMA-RBI	--		Switzerland	6913	91

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• AYPGKF-NH2, PAR4-AP
• ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT
• AYPGKF-NH2 TFA SALT
• PAR4-AP TFA SALT
• C34H48N8O7