ACBI1

2375564-55-7

CAS-Nr.: 2375564-55-7

Englisch Name:: ACBI1

Synonyma:: ACBI1;PROTACs,anti-proliferative,ACBI 1,Epigenetic Reader Domain,ACBI1,Inhibitor,Apoptosis,inhibit,ACBI-1;N-[(1-Fluorocyclopropyl)carbonyl]-3-methyl-L-valyl-(4R)-N-[2-{2-[4-({4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinyl}methyl)phenoxy]ethoxy}-4-(4-methyl-1,3-thiazol-5-yl)benzyl]-4-hydroxy-L-prolinamide;(2S,4R)-N-(2-(2-(4-((4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide

CBNumber:: CB75848938

Summenformel:: C49H58FN9O7S

Molgewicht:: 936.12

MOL-Datei:: 2375564-55-7.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 50

ACBI1 Eigenschaften

Siedepunkt:: 1144.1±65.0 °C(Predicted)

Dichte: 1.41±0.1 g/cm3(Predicted)

pka: 6.22±0.30(Predicted)

Aggregatzustand: Solid

Farbe: White to yellow

InChIKey: IVARZBJJMMUJHI-SSIILETPNA-N

SMILES: NC1N=NC(C2C=CC=CC=2O)=CC=1N1CCN(CC2C=CC(OCCOC3C=C(C4SC=NC=4C)C=CC=3CNC([C@@H]3C[C@@H](O)CN3C(=O)[C@H](C(C)(C)C)NC(C3(CC3)F)=O)=O)=CC=2)CC1 |&1:42,44,50,r|

Sicherheit

ACBI1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Definition

ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity and can induce apoptosis. It induced anti-proliferative effects and cell death caused by SMARCA2 depletion in SMARCA4 mutant cancer cells and acute myeloid leukemia cells dependent on SMARCA4 ATPase activity[1].

ACBI1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ACBI1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 50)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hubei Chuchang Biotech Co., Ltd.	+undefined15623860702	info@chuchangbiotech.com	China	111	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3581	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5225	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	3714	58
Changzhou Borl Biotechnology Co.,LTD	13606124132;13656121842	luyan0021@163.com	China	219	58

ACBI1
PROTACs,anti-proliferative,ACBI 1,Epigenetic Reader Domain,ACBI1,Inhibitor,Apoptosis,inhibit,ACBI-1
N-[(1-Fluorocyclopropyl)carbonyl]-3-methyl-L-valyl-(4R)-N-[2-{2-[4-({4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinyl}methyl)phenoxy]ethoxy}-4-(4-methyl-1,3-thiazol-5-yl)benzyl]-4-hydroxy-L-prolinamide
(2S,4R)-N-(2-(2-(4-((4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide
2375564-55-7
375564-55-7
C49H58FN9O7S