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ACBI1

ACBI1 구조식 이미지

카스 번호:: 2375564-55-7

상품명:: ACBI1

동의어(영문):: ACBI1;PROTACs,anti-proliferative,ACBI 1,Epigenetic Reader Domain,ACBI1,Inhibitor,Apoptosis,inhibit,ACBI-1;N-[(1-Fluorocyclopropyl)carbonyl]-3-methyl-L-valyl-(4R)-N-[2-{2-[4-({4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinyl}methyl)phenoxy]ethoxy}-4-(4-methyl-1,3-thiazol-5-yl)benzyl]-4-hydroxy-L-prolinamide;(2S,4R)-N-(2-(2-(4-((4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide

CBNumber:: CB75848938

분자식:: C49H58FN9O7S

포뮬러 무게:: 936.12

MOL 파일:: 2375564-55-7.mol

속성

안전

용도

공급 업체 49

ACBI1 속성

끓는 점: 1144.1±65.0 °C(Predicted)

밀도: 1.41±0.1 g/cm3(Predicted)

산도 계수 (pKa): 6.22±0.30(Predicted)

물리적 상태: Solid

색상: White to yellow

InChIKey: IVARZBJJMMUJHI-SSIILETPNA-N

SMILES: NC1N=NC(C2C=CC=CC=2O)=CC=1N1CCN(CC2C=CC(OCCOC3C=C(C4SC=NC=4C)C=CC=3CNC([C@@H]3C[C@@H](O)CN3C(=O)[C@H](C(C)(C)C)NC(C3(CC3)F)=O)=O)=CC=2)CC1 |&1:42,44,50,r|

안전

ACBI1 C화학적 특성, 용도, 생산

정의

ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity and can induce apoptosis. It induced anti-proliferative effects and cell death caused by SMARCA2 depletion in SMARCA4 mutant cancer cells and acute myeloid leukemia cells dependent on SMARCA4 ATPase activity[1].

ACBI1 준비 용품 및 원자재

원자재

준비 용품

ACBI1 공급 업체

글로벌( 49)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3512	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
Hubei Chuchang Biotech Co., Ltd.	+undefined15623860702	info@chuchangbiotech.com	China	116	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	4009	58
Changzhou Borl Biotechnology Co.,LTD	13606124132;13656121842	luyan0021@163.com	China	219	58