Edoxaban (tosylate Monohydrate)
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- CAS-Nr.
- 1229194-11-9
- Englisch Name:
- Edoxaban (tosylate Monohydrate)
- Synonyma:
- Edoxaban tosilate;edoxaban tosylate hydrate;Edoxaban Tosilate Monohydrate;Lixiana;Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonate, hydrate;CS-1597;Yidu Saban Mesylate;Edoxaban Tosylate Hydrate 1;Etuxaban p-toluenesulfonate;Edoxaban (TsOH salt hydrate)
- CBNumber:
- CB82645582
- Summenformel:
- C31H38ClN7O7S2
- Molgewicht:
- 720.26
- MOL-Datei:
- 1229194-11-9.mol
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Edoxaban (tosylate Monohydrate) Eigenschaften
- Schmelzpunkt:
- >252°C (dec.)
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- Löslichkeit
- Chloroform (Very Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Stabilität:
- Hygroscopic
- InChIKey
- ZLFZITWZOYXXAW-BUZWFPPCNA-N
- SMILES
- S(C1C=CC(C)=CC=1)(O)(=O)=O.N([C@@H]1C[C@@H](C(=O)N(C)C)CC[C@@H]1NC(=O)C(=O)NC1N=CC(Cl)=CC=1)C(C1SC2CN(C)CCC=2N=1)=O |&1:12,14,22,r|
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Edoxaban (tosylate Monohydrate) Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Edoxaban is an anticoagulant drug which acts as a direct factor Xa inhibitor.
Definition
ChEBI: A hydrate that is the monohydrate of the tosylate salt of edoxaban. Used for the treatment of deep vein thrombosis and pulmonary embolism.
Clinical Use
Daichi Sankyo’s edoxaban tosilate is an orally administered
coagulation factor Xa inhibitor that was approved and launched
in Japan for the preventive treatment of venous thromboembolic
events (VTE) in patients undergoing total knee arthroplasty, total
hip arthroplasty, or hip fracture surgery. Edoxaban has been
shown to have a rapid onset of anticoagulant effect due to short
Tmax (1–2 h) after dosing and sustained for up to 24 h post-dose.
Marketed under the brand name Lixiana, it is currently in phase
III studies in the US for the prevention of stroke and systemic embolic
events in patients with atrial fibrillation (AF) and venous
thromboembolism (VTE).
Edoxaban (tosylate Monohydrate) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Edoxaban (tosylate Monohydrate) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 251)Lieferanten
1229194-11-9()Verwandte Suche:
- Edoxaban (tosylate Monohydrate)
- Edoxaban p-toluenesulfonate monohydrate
- N-(5-Chloropyridin-2-yl)-N'-((1S,2R,4S)-4-[(dimethyl amino)carbonyl]-2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl)ethanediamide p-toluenesulfonate monohydrate
- N1-(5-Chloropyridin-2-yl)-N2-((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide 4-methylbenzenesulfonate hydrate
- Edoxaban Tosylate Hydrate 1
- Edoxaban (TsOH salt hydrate)
- CS-1597
- Edoxaban tosylate monohydrate(for Edoxaban)
- DU-176b tosylate Monohydrate
- Edoxaban (tosylate Monohydrate) USP/EP/BP
- Edoxaban tosylate monohydrate (DU-176b)
- Edoxaban tosilate
- Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonate, hydrate
- edoxaban tosylate hydrate
- Edoxaban Tosilate Monohydrate
- Lixiana
- Idoseban p-Toluenesulfonate Monohydrate
- Etuxaban p-toluenesulfonate
- Yidu Saban Mesylate
- Edoxaban Impurity 34 p-Toluenesulfonate Salt Monohydrate
- Edoxaban Impurity 29 p-Toluenesulfonate Salt
- 1229194-11-9
- C24H30ClN7O4SC7H8O3SH2O
- C31H40ClN7O8S2
- Inhibitors
- API
