Oxymorphon

OXYMORPHONE Struktur
76-41-5
CAS-Nr.
76-41-5
Bezeichnung:
Oxymorphon
Englisch Name:
OXYMORPHONE
Synonyma:
NSC 19045;NIH 10323;Numorphan;Oxymorphine;OXYMORPHONE;Oxymorphone (CRM);Dihydroxymorphinone;Naltrexone Impurity 15;OXYMORPHONE (MW 301.35);Dihydrohydroxymorphinone
CBNumber:
CB8317944
Summenformel:
C17H19NO4
Molgewicht:
301.34
MOL-Datei:
76-41-5.mol

Oxymorphon Eigenschaften

Schmelzpunkt:
248-249°C (dec)
Siedepunkt:
518.6±50.0 °C(Predicted)
Dichte
1.50±0.1 g/cm3(Predicted)
Flammpunkt:
9℃
storage temp. 
Controlled Substance, -20°C Freezer
Löslichkeit
Soluble in DMSO
Aggregatzustand
Powder
pka
pKa 8.50 (Uncertain);9.33 (Uncertain)
EPA chemische Informationen
Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-methyl-, (5.alpha.)- (76-41-5)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher F,T,T+
R-Sätze: 11-23/24/25-39/23/24/25-26/27/28
S-Sätze: 16-36/37-45-36/37/39-22
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
HS Code  2939110000
Giftige Stoffe Daten 76-41-5(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H336 Kann Schläfrigkeit und Benommenheit verursachen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Schläfrigkeit und Benommenheit) Warnung P261, P271, P304+P340, P312,P403+P233, P405, P501
Sicherheit

Oxymorphon Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Crystalline Solid

Verwenden

Controlled substance (opiate). Analgesic (narcotic)

Biologische Funktion

Oxymorphone is 10 times as potent as morphine, with actions similar to those of hydromorphone. Oxymorphone, however, has little antitussive activity, and as such is a useful analgesic in patients with pulmonary disease who need to retain the ability to cough.

Allgemeine Beschreibung

Oxymorphone is the 14 beta-hydroxyl version of hydromorphone,analogous to the hydrocodone, oxycodone pair discussedabove. Although the addition of the 14 beta-hydroxylgroup to hydrocodone (30 mg) yielded oxycodone (20 mg),a more potent drug, the opposite is true for the conversion ofhydromorphone (7.5 mg) to oxymorphone (10 mg). The reasonfor this is that the oral bioavailability of oxymorphone(10%) is lower than that of hydromorphone (35%) becauseof decreased absorption and increased first-pass metabolism.Presumably, the addition of the OH group does increaseits binding affinity at the receptor as the injectableform of oxymorphone (1 mg) is more potent than injectablehydromorphone (1.5 mg).
Oxymorphone is available as a suppository (5 mg), an injection(1 mg/mL), an immediate-release tablet (5 mg, 10mg), and in 2003 the FDA approved a sustained release formulation(Opana ER 5 mg, 10 mg, 20 mg, and 40 mg). The12-hour coverage of the extended release tablet provides anotheroption for those patients suffering from chronic pain.The side effect profile of the extended release formulationsof morphine, oxycodone, and oxymorphone are similar, andthere appears to be no clear advantage of one over the other.

Oxymorphon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

76-41-5(Oxymorphon)Verwandte Suche:


  • (5a)-4,5-Epoxy-3,14-dihydroxy-17-methyl-morphinan-6-one
  • NIH 10323
  • NSC 19045
  • 4,5-Epoxy-3,14-dihydroxy-N-methyl-6-oxomorphinan
  • OXYMORPHONE (MW 301.35)
  • Oxymorphone (base and/or unspecified salts)
  • (14S)-14-Hydroxydihydromorphinone
  • 14-Hydroxydihydromorphinone
  • 3,14-dihydroxy-4,5-alpha-epoxy-17-methyl-morphinan-6-on
  • 3,14-Dihydroxy-4,5-alpha-epoxy-17-methylmorphinan-6-one
  • 4,5alpha-Epoxy-3,14-dihydroxy-17-methylmorphinan-6-one
  • 5-epoxy-3,14-dihydroxy-17-methyl-(5-alpha)-morphinan-6-on
  • 7,8-Dihydro-14-hydroxymorphinone
  • Dihydro-14-hydroxymorphinone
  • Dihydro-14-hydroxymorphinonel 14-hydroxydihydromorphinone
  • Dihydrohydroxymorphinone
  • Dihydroxymorphinone
  • Morphinan-6-one, 3,14-dihydroxy-4,5-alpha-epoxy-17-methyl-
  • Morphinan-6-one, 4,5alpha-epoxy-3,14-dihydroxy-17-methyl-
  • Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-methyl-, (5alpha)-
  • Morphinone, dihydro-14-hydroxy-
  • Numorphan
  • Oxymorphine
  • OXYMORPHONE
  • Oxymorphone CII (500 mg)
  • Oxymorphone solution
  • 4,5α-Epoxy-3,14-dihydoroxy-17-methylmorphinan-6-one
  • 4,5α-Epoxy-3,14-dihydroxy-17-methylmorphinan-6-one
  • Oxymorphone (CRM)
  • (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one
  • Oxymorphone (controlled)
  • Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-methyl-, (5α)-
  • Oxymorphone CII (1488000)
  • Oxymorphone in Methanol(Solution)
  • Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-methyl-, (5α)-
  • 4,5α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one(oxymorphone),
  • Naltrexone Impurity 15
  • Hydroxycodone EP Impurity A
  • Oxymorphone CII (300 mg)
  • Nafamostat mesylate impurity G
  • Sodium naloxone impurity G
  • 76-41-5
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chiral Reagents
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