옥시모르폰
|
|
옥시모르폰 속성
- 녹는점
- 248-249°C (dec)
- 끓는 점
- 518.6±50.0 °C(Predicted)
- 밀도
- 1.50±0.1 g/cm3(Predicted)
- 인화점
- 9℃
- 저장 조건
- Controlled Substance, -20°C Freezer
- 용해도
- DMSO에 용해됨
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- pKa 8.50 (Uncertain);9.33 (Uncertain)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | F,T,T+ | ||
---|---|---|---|
위험 카페고리 넘버 | 11-23/24/25-39/23/24/25-26/27/28 | ||
안전지침서 | 16-36/37-45-36/37/39-22 | ||
유엔번호(UN No.) | UN1230 - class 3 - PG 2 - Methanol, solution | ||
WGK 독일 | 1 | ||
HS 번호 | 2939110000 | ||
유해 물질 데이터 | 76-41-5(Hazardous Substances Data) |
옥시모르폰 C화학적 특성, 용도, 생산
화학적 성질
Crystalline Solid용도
Controlled substance (opiate). Analgesic (narcotic)Biological Functions
Oxymorphone is 10 times as potent as morphine, with actions similar to those of hydromorphone. Oxymorphone, however, has little antitussive activity, and as such is a useful analgesic in patients with pulmonary disease who need to retain the ability to cough.일반 설명
Oxymorphone is the 14 beta-hydroxyl version of hydromorphone,analogous to the hydrocodone, oxycodone pair discussedabove. Although the addition of the 14 beta-hydroxylgroup to hydrocodone (30 mg) yielded oxycodone (20 mg),a more potent drug, the opposite is true for the conversion ofhydromorphone (7.5 mg) to oxymorphone (10 mg). The reasonfor this is that the oral bioavailability of oxymorphone(10%) is lower than that of hydromorphone (35%) becauseof decreased absorption and increased first-pass metabolism.Presumably, the addition of the OH group does increaseits binding affinity at the receptor as the injectableform of oxymorphone (1 mg) is more potent than injectablehydromorphone (1.5 mg).Oxymorphone is available as a suppository (5 mg), an injection(1 mg/mL), an immediate-release tablet (5 mg, 10mg), and in 2003 the FDA approved a sustained release formulation(Opana ER 5 mg, 10 mg, 20 mg, and 40 mg). The12-hour coverage of the extended release tablet provides anotheroption for those patients suffering from chronic pain.The side effect profile of the extended release formulationsof morphine, oxycodone, and oxymorphone are similar, andthere appears to be no clear advantage of one over the other.
옥시모르폰 준비 용품 및 원자재
원자재
수소
브롬화수소
터바인;모르피난,6,7,8,14-테트라데하이드로-4,5-알파-에폭시-3,6-다이메톡시-17-메틸-
과산화 수소
7,8-Dihydro-14-hydroxy- normorphinone
준비 용품
옥시모르폰 관련 검색:
옥시코돈
Naloxone hydrochloride dihydrate
OXYMORPHONE
Semorphone
Naltrexone hydrochloride
Naloxone hydrochloride
OXYCODONE HYDROCHLORIDE
Naltrexone
OXYMORPHONE HCL NARCOTIC ANALGESIC,oxymorphone hydrochloride
Naloxone
Naltrexone 3-O-β-D-Glucuronide
Nalmexonum
Oxymorphone-d3
NALOXONE, [N-ALLYL 2,3-3H]
7-BENZYLIDENENALTREXONE MALEATE
OXYCODONE-D6
OXYCODONE HYDROCHLORIDE, [7,8-3H]
OXYCODONE-D3