터바인;모르피난,6,7,8,14-테트라데하이드로-4,5-알파-에폭시-3,6-다이메톡시-17-메틸-
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터바인;모르피난,6,7,8,14-테트라데하이드로-4,5-알파-에폭시-3,6-다이메톡시-17-메틸- 속성
- 녹는점
- 183-186°C (dec.)
- 알파
- D15 -219° (p = 2 in alc); D23 -230° (p = 5 in chloroform)
- 끓는 점
- 451.42°C (rough estimate)
- 밀도
- 1.3050
- 굴절률
- 1.5000 (estimate)
- 저장 조건
- Controlled Substance, -20°C Freezer
- 용해도
- H2O: 2.2 mg/mL, 약간 용해됨
- 산도 계수 (pKa)
- 6.05(at 15℃)
- 물리적 상태
- 가루
- 수용성
- <10mg/L(상온)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T+ | ||
---|---|---|---|
위험 카페고리 넘버 | 26/27/28 | ||
안전지침서 | 22-36/37/39-45 | ||
유엔번호(UN No.) | UN 1544 6.1/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | QD2975000 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III |
터바인;모르피난,6,7,8,14-테트라데하이드로-4,5-알파-에폭시-3,6-다이메톡시-17-메틸- C화학적 특성, 용도, 생산
개요
The naturally occurring opiate alkaloid thebaine is present in high concentrations in poppy straw; lower concentrations of the co deine alkaloid are present.화학적 성질
Tan Solid용도
Thebaine is present in opium at 0.3–1.5%.It is extracted from opium or from latex ofthe plant Papaver bracteatum, in which it ispresent at up to 26%. It is used to producecodeine.위험도
Toxic by ingestion, may induce addiction.건강위험
Although thebaine has a morphine- orcodeine-like structure, its pharmacologyaction is somewhat different. It is a convulsantpoison like strychnine, rather thana narcotic. High doses can cause ataxia andconvulsionLD50 value, intraperitoneal (mice): 42 mg/kg
Thebaine is a habit-forming compound. Itis a controlled substance (opiate) listed underU.S. Code of Federal Regulations (Title 21Part 1308.12, 1985).
색상 색인 번호
The naturally occurring opiate alkaloid thebaine is present in concentrated poppy straw, and in small concentrations in codeine alkaloid. It is used in the manufacture of other opiate pharmaceuticals, such as buprenorphine and morphine, and caused contact dermatitis in a laboratory worker at an opiates manufacturing pharmaceutical company, also sensitive to codeine.Purification Methods
Crystallise Thebaine from Et2O or EtOH. Sublime it at 170-180o. The hydrochloride decomposes >182o (from MeOH/Et2O). [Beilstein 27 II 177, 27 III/IV 2271.] It is a NARCOTIC.참고 문헌
Pelletier, Thiboumery., Annalen, 16,38 (1835)Kane., ibid, 19, 9 (1836)
Anderson., ibid, 86, 184 (1853)
Howerd., Ber., 17,527 (1884)
Pschorr, Zeidler., ibid, 27,2961 (1894)
Freund, Michaels, Gobel., ibid, 30, 1357 (1897)
Knorr., ibid, 36, 3074 (1903)
Freund, Holthof., ibid, 37, 2780 (1904)
Pschorr, Pfaff, Herrschmann., ibid, 38, 3163 (1905)
Reichard., Pharm. Zeit., 47,623 (1906)
Hildebrandt., Arch. expo Path. Pharm., 65,54 (1911)
Kruger, Eddy, Sumwalt., Suppl. No. 165, Public Health Reports, Washington (1943)
Flieschhacker, Pasal, Vieboeck., Monatsh., 99, 300 (1968)
Eppenberger, Warren, Repoport., Helv. Chim. Acta, 51,381 (1968)
터바인;모르피난,6,7,8,14-테트라데하이드로-4,5-알파-에폭시-3,6-다이메톡시-17-메틸- 준비 용품 및 원자재
원자재
코디논
Morphinan, 6,7,8,14-tetradehydro-4,5-epoxy-3,6-dimethoxy-17-methyl-5-(trimethylsilyl)-, (5β)-
Morphinan, 7,8-didehydro-4,5-epoxy-3,6,6-trimethoxy-17-methyl-, (5α)-
(5alpha)-6,7-didehydro-4,5-epoxy-3,6-dimethoxy-17-methylmorphinan
하이드로코돈
6-O-METHYLCODEINE
오소 포름산 메틸
코데인
준비 용품
터바인;모르피난,6,7,8,14-테트라데하이드로-4,5-알파-에폭시-3,6-다이메톡시-17-메틸- 관련 검색:
오르토-삼차뷰틸페놀 2-(2-히드록시에톡시)페놀
3-ISOPROPYLCATECHOL
1,5-HEXADIEN-3-OL
2-(1,1-DIMETHYLPROPYL)PHENOL
4-Piperidineethanol
3-METHOXYPHENETHYL ALCOHOL
(R)-4-AMINO-2-METHYL-1-BUTANOL
1-METHOXY-1,3-BUTADIENE
(R)-(-)-1-Methyl-3-phenylpropylamine
3-ISOPROPYLPHENOL
THEBAINE
4,4-dimethylpiperidine
Drotebanol
THEBAINONE
ISOTHEBAINE
OPIUM
3-(3-METHOXY-PHENYL)-PROPYLAMINE