(5alpha)-6,7,8,14-tetradehydro-4,5-epoxy-6-methoxy-17-methylmorphinan-3-ol C화학적 특성, 용도, 생산
개요
This alkaloid was first obtained from the leaves of Papaver orientalis by moistening the dried leaves with ammonia and extracting them with CH2CI2. Subsequently it has been isolated from P. bracteaturn and on recrystallization from
EtOH it forms colourless needles. It is readily soluble in CHCI3, sparingly so in
EtOH and Me2CO and insoluble in H20. It is laevorotatory with [α]D - 211.8°
(CHC13) and yields a hydrochloride, m.p. 258-9°C (dec.) and a methiodide, m.p.
207-8°C. The alkaloid dissolves in aqueous NaOH yielding a crystalline sodium
derivative.
화학적 성질
Light Tan Solid
용도
The major metabolite of Thebaine. Oripavine possesses an analgesic potency comparable to Morphine; it is not clinically useful due to severe toxicity and low therapeutic index. An opiate.
