AZ 12216052

1290628-31-7

CAS-Nr.: 1290628-31-7

Englisch Name:: AZ 12216052

Synonyma:: AZ 12216052;AZ12216052 >=98% (HPLC);2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide;Acetamide, 2-[[(4-bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]-

CBNumber:: CB93146258

Summenformel:: C19H22BrNOS

Molgewicht:: 392.35308

MOL-Datei:: 1290628-31-7.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 15

AZ 12216052 Eigenschaften

Siedepunkt:: 526.9±45.0 °C(Predicted)

Dichte: 1.323±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: DMSO: soluble

Aggregatzustand: A crystalline solid

pka: 13.70±0.70(Predicted)

Farbe: White to off-white

Sicherheit

AZ 12216052 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

AZ 12216052 is a positive allosteric modulator of metabotropic glutamate receptor 8 (mGluR8). It potentiates glutamate-induced [³⁵S]GTPγS binding in GHEK cells expressing human mGluR8b (EC₅₀ = 1 μM). In a cell-based model of Parkinson’s disease, AZ 12216052 inhibits MPP⁺-induced decreases in the viability of undifferentiated SH-SY5Y cells when used at concentrations ranging from 0.001 to 1 μM and in retinoic acid-differentiated SH-SY5Y cells at 0.1 and 1 μM. AZ 12216052 (10 mg/kg) increases the time spent in the open areas of the elevated zero maze and reduces the acoustic startle response in mice, indicating anxiolytic-like activity in response to avoidable and unavoidable anxiogenic stimuli, respectively.

AZ 12216052 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

AZ 12216052 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 15)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9941	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44843	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23963	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4565	58

AZ 12216052
2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide
AZ12216052 >=98% (HPLC)
Acetamide, 2-[[(4-bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]-
1290628-31-7