AZ 12216052
- CAS No.
- 1290628-31-7
- Chemical Name:
- AZ 12216052
- Synonyms
- AZ 12216052;AZ12216052 >=98% (HPLC);2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide;Acetamide, 2-[[(4-bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]-
- CBNumber:
- CB93146258
- Molecular Formula:
- C19H22BrNOS
- Molecular Weight:
- 392.35308
- MDL Number:
- MFCD20926426
- MOL File:
- 1290628-31-7.mol
AZ 12216052 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29460 | AZ 12216052 | 1290628-31-7 | 5mg | $104 | 2024-03-01 | Buy |
| Cayman Chemical | 29460 | AZ 12216052 | 1290628-31-7 | 25mg | $412 | 2024-03-01 | Buy |
| Cayman Chemical | 29460 | AZ 12216052 | 1290628-31-7 | 1mg | $38 | 2024-03-01 | Buy |
| Cayman Chemical | 29460 | AZ 12216052 | 1290628-31-7 | 10mg | $184 | 2024-03-01 | Buy |
| Tocris | 4832 | AZ12216052 ≥97%(HPLC) | 1290628-31-7 | 10 | $170 | 2021-12-16 | Buy |
AZ 12216052 Chemical Properties,Uses,Production
Description
AZ 12216052 is a positive allosteric modulator of metabotropic glutamate receptor 8 (mGluR8). It potentiates glutamate-induced [35S]GTPγS binding in GHEK cells expressing human mGluR8b (EC50 = 1 μM). In a cell-based model of Parkinson’s disease, AZ 12216052 inhibits MPP+-induced decreases in the viability of undifferentiated SH-SY5Y cells when used at concentrations ranging from 0.001 to 1 μM and in retinoic acid-differentiated SH-SY5Y cells at 0.1 and 1 μM. AZ 12216052 (10 mg/kg) increases the time spent in the open areas of the elevated zero maze and reduces the acoustic startle response in mice, indicating anxiolytic-like activity in response to avoidable and unavoidable anxiogenic stimuli, respectively.
Uses
AZ 12216052 is a positive allosteric modulator of mGluR8, which are attractive therapeutic targets for anxiety disorders.
AZ 12216052 Preparation Products And Raw materials
Raw materials
Preparation Products
AZ 12216052 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9833 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4249 | 58 |