N-[5-[[(3-Amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-1H-pyrrol-2-carboxamidmonohydrochlorid

N-[5-[[(3-Amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-1H-pyrrol-2-carboxamidmonohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R43:Sensibilisierung durch Hautkontakt möglich.

S-Sätze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Originator

Herperal,Farmitalia,Italy,1978

Manufacturing Process

A spore suspension obtained upon washing a culture of Streptomyces distallicus is added to 3,000 ml of a sterile medium consisting of the following:Dextrose 2% Corn steep liquor extract 2% CaCO3 1% (NH4)2SO4 0.3% NaCl 0.3%Fermentation is continued at 28°C for 40 hours at a stirring rate of 150 to 250 rpm and a rate of air flow of 1 to 2 l/min/l of culture medium.
300 ml of a suspension of the vegetative mycelium of this culture are used for inoculating 6,000 ml of a similar sterile culture medium. At this production stage, the culture is kept fermenting for 85 to 100 hours (pH 7.6 at 28°C) at a stirring rate of 350 to 450 rpm and a rate of air flow of 1 to 1.5 l/min/l of culture medium.
To 17 l of a culture obtained by submerged fermentation as mentioned above, siliceous earth is added and the batch is filtered. The mixture of mycelium and the siliceous earth are agitated for 1 hour with 2.5 l of butanol. This treatment is repeated twice. The butanolic extracts are combined, washed with water, evaporated to dryness (about 10 g) and boiled with acetone (80 ml). The 5 g of distamycin is extracted six times with ethanol. The ethanolic extracts are combined, concentrated and filtered through a column containing 70 g of alumina. Elution is carried out with the same solvent. The effluent (central fractions) is collected and evaporated to dryness to yield 0.43 g of pure distamycin A: decomposition point, 183°C to 185°C. The product can be further purified by crystallization from aqueous n-butanol.

Therapeutic Function

Antibiotic

N-[5-[[(3-Amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-1H-pyrrol-2-carboxamidmonohydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-[5-[[(3-Amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-1H-pyrrol-2-carboxamidmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21673	55
TopScience Biochemical	00852-68527855	info@itopbiochem.com	China Hong Kong	902	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Chizhou Kailong Import and Export Trade Co., Ltd.		xg01_gj@163.com	China	9503	50
Hangzhou Synstar pharmaceutical Technology CO.,Ltd	0571-85361029	synstar518@163.com	China	1991	58
Shaanxi Dideu Newmaterial Co., Ltd.	029-63373950 15353716720	1052@dideu.com	China	10011	58
Hubei Enxing Biotechnology Co., Ltd	16621771607	exbio_tech@163.com	China	8327	58

6576-51-8(N-[5-[[(3-Amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-1H-pyrrol-2-carboxamidmonohydrochlorid)Verwandte Suche:

---

• 1H-Pyrrole-2-carboxaMide,N-[5-[[(3-aMino-3-iMinopropyl)aMino]carbonyl]-1-Methyl-1H-pyrrol-3-yl]-4-[[[4-(forMylaMino)-1-Methyl-1H-pyrrol-2-yl]carbonyl]aMino]-1-Methyl-,hydrochloride (1:1)
• N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-me
• distamycin A hydrochloride from*streptomyces dist
• N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-1H-pyrrole-2-carboxamide monohydrochloride
• Distamycin A hydrochloride from Streptomyces distallicus
• MEN-10399
• DISTAMYCIN A HYDROCHLORIDE FROM*STREPTOM YCES DISTAL
• estalimicinaclorhidrato
• fi6426
• herperal
• stallimycinhydrochloride
• DISTAMYCIN A HCL
• DISTAMYCIN A HYDROCHLORIDE
• 6576-51-8
• C22H27N9O4HCl
• C22H28O4N9Cl
• Antibiotics A to Z
• Antibiotics A-F
• Antibiotics
• BioChemical