DISTAMYCIN A HYDROCHLORIDE
- CAS No.
- 6576-51-8
- Chemical Name:
- DISTAMYCIN A HYDROCHLORIDE
- Synonyms
- fi6426;herperal;MEN-10399;DISTAMYCIN A HCL;estalimicinaclorhidrato;stallimycinhydrochloride;DISTAMYCIN A HYDROCHLORIDE;distamycin A hydrochloride from*streptomyces dist;DISTAMYCIN A HYDROCHLORIDE FROM*STREPTOM YCES DISTAL;Distamycin A hydrochloride from Streptomyces distallicus
- CBNumber:
- CB9316227
- Molecular Formula:
- C22H28ClN9O4
- Molecular Weight:
- 517.97
- MDL Number:
- MFCD00058165
- MOL File:
- 6576-51-8.mol
Melting point | 184-187° (Arcamone, 1967). Also reported as 189-193° from ethanol-ethyl acetate (Bialer) |
---|---|
storage temp. | −20°C |
FDA UNII | F6010N240F |
DISTAMYCIN A HYDROCHLORIDE Chemical Properties,Uses,Production
Originator
Herperal,Farmitalia,Italy,1978
Manufacturing Process
A spore suspension obtained upon washing a culture of Streptomyces
distallicus is added to 3,000 ml of a sterile medium consisting of the
following:Dextrose 2%
Corn steep liquor extract 2%
CaCO3 1%
(NH4)2SO4 0.3%
NaCl 0.3%Fermentation is continued at 28°C for 40 hours at a stirring rate of 150 to 250
rpm and a rate of air flow of 1 to 2 l/min/l of culture medium.
300 ml of a suspension of the vegetative mycelium of this culture are used for
inoculating 6,000 ml of a similar sterile culture medium. At this production
stage, the culture is kept fermenting for 85 to 100 hours (pH 7.6 at 28°C) at
a stirring rate of 350 to 450 rpm and a rate of air flow of 1 to 1.5 l/min/l of
culture medium.
To 17 l of a culture obtained by submerged fermentation as mentioned above,
siliceous earth is added and the batch is filtered. The mixture of mycelium and
the siliceous earth are agitated for 1 hour with 2.5 l of butanol. This treatment
is repeated twice. The butanolic extracts are combined, washed with water,
evaporated to dryness (about 10 g) and boiled with acetone (80 ml). The 5 g of distamycin is extracted six times with ethanol. The ethanolic extracts
are combined, concentrated and filtered through a column containing 70 g of
alumina. Elution is carried out with the same solvent. The effluent (central
fractions) is collected and evaporated to dryness to yield 0.43 g of pure
distamycin A: decomposition point, 183°C to 185°C. The product can be
further purified by crystallization from aqueous n-butanol.
Therapeutic Function
Antibiotic
DISTAMYCIN A HYDROCHLORIDE Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
Chizhou Kailong Import and Export Trade Co., Ltd. | xg01_gj@163.com | China | 9503 | 50 | |
Hangzhou Synstar pharmaceutical Technology CO.,Ltd | 0571-85361029 | synstar518@163.com | China | 1991 | 58 |
Shaanxi Dideu Newmaterial Co., Ltd. | 029-63373950 15353716720 | 1052@dideu.com | China | 10011 | 58 |
Hubei Enxing Biotechnology Co., Ltd | 16621771607 | exbio_tech@163.com | China | 8256 | 58 |
6576-51-8(DISTAMYCIN A HYDROCHLORIDE)Related Search:
1of2