BMS-763534

1188407-40-0

CAS-Nr.: 1188407-40-0

Englisch Name:: BMS-763534

Synonyma:: BMS-763534;BMS-763534 >=98% (HPLC);2(1H)-Pyrazinone, 5-chloro-1-[(1S)-1-cyclopropyl-2-methoxyethyl]-3-[[6-(difluoromethoxy)-2,5-dimethyl-3-pyridinyl]amino]-

CBNumber:: CB94669866

Summenformel:: C18H21ClF2N4O3

Molgewicht:: 414.83

MOL-Datei:: 1188407-40-0.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 4

BMS-763534 Eigenschaften

Schmelzpunkt:: 103.4-104.4 °C(Solv: heptane (142-82-5))

Siedepunkt:: 470.4±55.0 °C(Predicted)

Dichte: 1.45±0.1 g/cm3(Predicted)

storage temp.: room temp

pka: 1.89±0.40(Predicted)

Aggregatzustand: powder

Farbe: white to beige

Optische Aktivität: [α]/D -40 to -55°, c = 0.8 in chloroform-d

Sicherheit

BMS-763534 Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

BMS-763534 is a pyrazinone-containing antagonist that targets corticotropin-releasing factor/hormone (CRF or CRH) receptor 1 (CRF1, CRF-R1, CRFR-1, CRH-R1, CRHR-1) with high affinity (IC50 = 0.26 & 0.4 nM against 150 pM ovine CRF for binding rat & human CRF-R1, respectively), potency (IC50 = 1.0 nM against 0.3 nM CRF-stimulated ATCH secretion from primary rat anterior pituitary cells), and selectivity, displaying little affinity toward porcine CRF-R2/CRF2 and 46 other receptor/channel/transporter proteins (IC50 >10 μM). BMS-763534 inhibits CRF-stimulated cAMP production in human Y-79 retinoblastoma cells in cultures (pA2 = 9.47) and exhibits anxiolytic efficacy in a rat situational anxiety model in vivo (0.5-3 mg/kg p.o.).

BMS-763534 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

BMS-763534 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 4)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+8613564774135	zijue.cai@tsbiochem.com	United States	19863	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44808	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19711	58

BMS-763534
BMS-763534 >=98% (HPLC)
2(1H)-Pyrazinone, 5-chloro-1-[(1S)-1-cyclopropyl-2-methoxyethyl]-3-[[6-(difluoromethoxy)-2,5-dimethyl-3-pyridinyl]amino]-
1188407-40-0