BMS-763534
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BMS-763534 속성
- 녹는점
- 103.4-104.4 °C(Solv: heptane (142-82-5))
- 끓는 점
- 470.4±55.0 °C(Predicted)
- 밀도
- 1.45±0.1 g/cm3(Predicted)
- 저장 조건
- room temp
- 산도 계수 (pKa)
- 1.89±0.40(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
- optical activity
- [α]/D -40 to -55°, c = 0.8 in chloroform-d
안전
BMS-763534 C화학적 특성, 용도, 생산
Biochem/physiol Actions
BMS-763534 is a pyrazinone-containing antagonist that targets corticotropin-releasing factor/hormone (CRF or CRH) receptor 1 (CRF1, CRF-R1, CRFR-1, CRH-R1, CRHR-1) with high affinity (IC50 = 0.26 & 0.4 nM against 150 pM ovine CRF for binding rat & human CRF-R1, respectively), potency (IC50 = 1.0 nM against 0.3 nM CRF-stimulated ATCH secretion from primary rat anterior pituitary cells), and selectivity, displaying little affinity toward porcine CRF-R2/CRF2 and 46 other receptor/channel/transporter proteins (IC50 >10 μM). BMS-763534 inhibits CRF-stimulated cAMP production in human Y-79 retinoblastoma cells in cultures (pA2 = 9.47) and exhibits anxiolytic efficacy in a rat situational anxiety model in vivo (0.5-3 mg/kg p.o.).BMS-763534 준비 용품 및 원자재
원자재
준비 용품
BMS-763534 공급 업체
글로벌( 3)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
| Energy Chemical | 021-58432009 400-005-6266 |
marketing1@energy-chemical.com | China | 44843 | 58 |
| TargetMol Chemicals Inc. | 15002134094 |
marketing@targetmol.cn | China | 28091 | 58 |