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PF-06700841 tosylate

PF-06700841 tosylate Struktur
1883299-62-4
CAS-Nr.
1883299-62-4
Englisch Name:
PF-06700841 tosylate
Synonyma:
PF841;PF 841;PF-841;CS-2861;PF6700841;PF 6700841;PF-6700841;PF-06700841 tosylate;Brepocitinib (PF-06700841);inhibit,Janus kinase,PF06700841,JAK,Brepocitinib,Inhibitor,PF 06700841
CBNumber:
CB94674167
Summenformel:
C18H21F2N7O
Molgewicht:
389.4
MOL-Datei:
1883299-62-4.mol
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PF-06700841 tosylate Eigenschaften

Siedepunkt:
637.1±65.0 °C(Predicted)
Dichte
1.63±0.1 g/cm3(Predicted)
storage temp. 
room temp
Löslichkeit
DMSO: 78 mg/mL (200.31 mM);Ethanol: 78 mg/mL (200.31 mM)
Aggregatzustand
powder
pka
7.28±0.10(Predicted)
Farbe
white to beige
Wasserlöslichkeit
Water: Insoluble

Sicherheit

PF-06700841 tosylate Chemische Eigenschaften,Einsatz,Produktion Methoden

Charakteristisch

Class: non-receptor tyrosine kinase
Treatment: immunological disorders
Other name: PF-06700841; Brepocitinib
Elimination half-life = 3.8–7.5 h
Protein binding = 39%

Verwenden

PF-06700841 tosylate salt has been used as an inhibitor of Janus kinase1 (JAK1) to study its therapeutic effect on the adjuvant induced arthritis (AIA) rat model. It has also been used as an inhibitor of interferon-α/β receptor alpha chain (IFNAR1) signaling adaptor tyrosine kinase (2TYK2) in mice.

Biochem/physiol Actions

PF-06700841 prevents IL-23 (interleukin 23) signaling through TYK2 (Tyrosine-protein kinase 2)/JAK1 (Janus kinase 1) inhibition.

PF-06700841 tosylate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PF-06700841 tosylate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 70)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32836 60
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830
 figo.gao@foxmail.com China 7621 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289
 contact@trustwe.com China 5738 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196
 sale04@alfachem.cn China 13341 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30250 58
NINGBOBENKANGJS PHARMTECHCO., LTD 		+8615990591583 15990591583
 CHINA 2029 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6313 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10522 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 24738 58
  • PF-06700841 tosylate
  • ((S)-2,2-difluorocyclopropyl)(3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone
  • PF 6700841
  • PF-06700841; PF 06700841; PF06700841; PF-6700841; PF 6700841; PF6700841; PF-06700841 TOSYLATE SALT
  • PF6700841
  • PF-6700841
  • CS-2861
  • ((S)-2,2-difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone
  • Methanone, [(1S)-2,2-difluorocyclopropyl][3-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-
  • Brepocitinib (PF-06700841)
  • inhibit,Janus kinase,PF06700841,JAK,Brepocitinib,Inhibitor,PF 06700841
  • PF 841
  • PF841
  • PF-841
  • 1883299-62-4
  • C18H21F2N7O
  • api
  • APIS
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