Harnsure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R33:Gefahr kumulativer Wirkungen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Uric acid (C5H4O3N4) is a white solid that is insoluble in cold water, alcohol, or ether and sparingly soluble in hot water. It acts as a weak dibasic acid, creating two series of salts, with most being very slightly soluble in water (except for lithium urate, which is soluble).
Occurrence
Uric acid is found in the urine, blood, and muscle juices of carnivorous animals (herbivorous animals secrete hippuric acid), in the excrement of birds, serpents and insects, and is an oxidation product of the complex nitrogenous compounds of the animal organism.
Verwenden
Uric Acid is a heterocyclcic compound that is created when purine nucleotides are broken down of by the human body. High blood concetration of Uric Acid is known as hyperuricemia and is often associated with a wide range of disorders and medical conditions such as gout, diabetes and metabolic syndrome. Uric acid may be a marker of oxidative stress and may have a potential therapeutic role as an antioxidant.
Definition
A nitrogen compound
produced from purines. In certain animals
(e.g. birds and reptiles), it is the main excretory product resulting from breakdown
of amino acids. In humans, uric acid crystals in the joints are the cause of gout.
Sicherheitsprofil
Experimental
reproductive effects. Mutation data
reported. When heated to decomposition it
emits toxic fumes of NOx.
läuterung methode
Crystallise uric acid from hot distilled H2O (the solubility in H2O is 1part/39,000parts at 18o and 1part/2,000parts at 100o). It is best purified by dissolving in an alkaline solution and acidifying with dilute HCl and drying it at 100o in a vacuum. [Bergmann & Dikstein J Am Chem Soc 77 691 1955, Lister Purines Part II, Fused Pyrimidines Brown Ed, Wiley-Interscience pp256-257 1971, ISBN 0-471-38205-1, Beilstein 26 H 513, 26 I 151, 26 II 293, 26 III/IV 2619.]
Einzelnachweise
Regulation of uric acid metabolism and excretion DOI:
10.1002/RECL.19881071209Purification of Laboratory Chemicals, Fourth Edition. By W. L. F. DOI:
10.1002/RECL.19881071209Van Nostrand’s Scientific Encyclopedia
DOI:10.1007/978-1-4757-6918-0
The Facts on File Dictionary of Chemistry DOI:
10.5860/choice.37-4227A Dictionary of Chemistry (6th edition) DOI:
10.1108/09504120910935291Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis DOI:
10.3390/ijms222212394
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