Nintedanib Esylate
- CAS No.
- 656247-18-6
- Chemical Name:
- Nintedanib Esylate
- Synonyms
- Nintedanib esylate;Nintedanib ethanesulfonate;Nintedani;NSC 116056;BIBF-1120 esylate;BIBF 1120 esylate;Nintedanib (Ofev);BIBF 1120 BIBF-1120;Trinidad Neeb esylate;Intedanib ethanesulfonate
- CBNumber:
- CB00123189
- Molecular Formula:
- C33H39N5O7S
- Molecular Weight:
- 649.76
- MDL Number:
- MFCD26142360
- MOL File:
- 656247-18-6.mol
- MSDS File:
- SDS
Melting point | >233°C (dec.) |
---|---|
storage temp. | -20°C Freezer |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Yellow solid. |
color | Light Yellow to Yellow |
FDA UNII | 42F62RTZ4G |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
NFPA 704 |
|
Nintedanib Esylate price More Price(37)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | N478290 | NintedanibEsylate | 656247-18-6 | 5mg | $65 | 2021-12-16 | Buy |
ChemScene | CS-3475 | Nintedanibesylate 99.93% | 656247-18-6 | 10mg | $66 | 2021-12-16 | Buy |
AK Scientific | 9942AL | Nintedanibesylate | 656247-18-6 | 25mg | $67.2 | 2021-12-16 | Buy |
ChemScene | CS-3475 | Nintedanibesylate 99.93% | 656247-18-6 | 50mg | $96 | 2021-12-16 | Buy |
Biosynth Carbosynth | FD71497 | Nintedanib ethanesulfonate | 656247-18-6 | 50mg | $100 | 2021-12-16 | Buy |
Nintedanib Esylate Chemical Properties,Uses,Production
Description
Nintedanib esylate is an organosulfonate salt obtained by combining nintedanib with one molar equivalent of ethanesulfonic acid. A kinase inhibitor used for the treatment of idiopathic pulmonary fibrosis and cancer. It has a role as an angiogenesis inhibitor, an antineoplastic agent, a fibroblast growth factor receptor antagonist, a tyrosine kinase inhibitor, and a vascular endothelial growth factor receptor antagonist. Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
Mechanism of action
Nintedanib Esylate is the salt form of Nintedanib. Nintedanib is a small molecule, competitive, triple angiokinase inhibitor that targets multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs). Many of these RTKs are implicated in lung fibrosis and tumor angiogenesis, so nintedanib is used to treat proliferative diseases such as idiopathic pulmonary fibrosis, non-small cell lung cancer, and systemic sclerosis-associated interstitial lung disease. The specific RTKs that nintedanib inhibits are platelet-derived growth factor (PDGFR) α and β, fibroblast growth factor receptor (FGFR) 1-3, vascular endothelial growth factor receptor (VEGFR) 1-3, and Fns-Like tyrosine kinase-3 (FLT3). Nintedanib binds to the ATP-binding pocket of these receptors and inhibits their activity, thereby blocking signaling cascades that result in the proliferation and migration of lung fibroblasts. Nintedanib also inhibits kinase signaling pathways in various cells within tumor tissues, including endothelial cells, pericytes, smooth muscle cells, and cells contributing to angiogenesis, culminating in an inhibition of cell proliferation and apoptosis of affected tumor cells.
Nintedanib Esylate Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
HangZhou RunYan Pharma Technology Co.,LTD. | +8618882027439 | sales2@runyanpharma.com | China | 304 | 58 |
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 | sales@sjar-tech.com | China | 297 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 | bj1@bj-chem.com | China | 299 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21663 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9284 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
View Lastest Price from Nintedanib Esylate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-29 | Nintedanib Esylate
656247-18-6
|
US $0.00 / g | 1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | ||
2021-07-02 | Nintedanib esylate
656247-18-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2019-07-06 | Nintedanib Esylate
656247-18-6
|
US $1.00 / KG | 1KG | 98% | 500kg | Career Henan Chemical Co |
- Nintedanib Esylate
656247-18-6
- US $0.00 / g
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
- Nintedanib esylate
656247-18-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Nintedanib Esylate
656247-18-6
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
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