3-ACETAMIDOPHENOL
- CAS No.
- 621-42-1
- Chemical Name:
- 3-ACETAMIDOPHENOL
- Synonyms
- Nebs;bs479;BS 749;BS 479;Rystal;Metalid;Pyrapap;Pedituss;NSC 3990;metacetamol
- CBNumber:
- CB0108898
- Molecular Formula:
- C8H9NO2
- Molecular Weight:
- 151.16
- MDL Number:
- MFCD00002263
- MOL File:
- 621-42-1.mol
- MSDS File:
- SDS
| Melting point | 145-148 °C(lit.) |
|---|---|
| Boiling point | 273.17°C (rough estimate) |
| Density | 1.249 |
| refractive index | 1.5810 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol |
| pka | 9.50±0.10(Predicted) |
| form | Crystals, Crystalline Powder or Needles |
| color | Off-white to tan or light gray |
| PH | 6-7 (H2O)(saturated solution) |
| BRN | 907998 |
| CAS DataBase Reference | 621-42-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | V942ZCN81H |
| EPA Substance Registry System | 3'-Hydroxyacetanilide (621-42-1) |
| UNSPSC Code | 77101502 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | AE4100000 | |||||||||
| F | 1-8 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29242995 | |||||||||
| Toxicity | LD50 intraperitoneal in mouse: 1025mg/kg | |||||||||
| NFPA 704 |
|
3-ACETAMIDOPHENOL price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A7205 | 3-Acetamidophenol 97% | 621-42-1 | 25g | $57.9 | 2023-06-20 | Buy |
| Sigma-Aldrich | 19374 | 3-Acetamidophenol analytical standard | 621-42-1 | 100mg | $95.9 | 2022-05-15 | Buy |
| TCI Chemical | H0188 | 3'-Hydroxyacetanilide >98.0%(T) | 621-42-1 | 25g | $28 | 2024-03-01 | Buy |
| TCI Chemical | H0188 | 3'-Hydroxyacetanilide >98.0%(T) | 621-42-1 | 500g | $227 | 2024-03-01 | Buy |
| Alfa Aesar | A12764 | 3-Acetamidophenol, 99% | 621-42-1 | 25g | $26.65 | 2024-03-01 | Buy |
3-ACETAMIDOPHENOL Chemical Properties,Uses,Production
Chemical Properties
off-white to tan or light grey crystals,
Uses
3-Acetamidophenol is the ortho-regioisomer of Acetaminophen (A161220), an over-the-counter analgesic and antipyretic agent (1,2).
Definition
ChEBI: A derivative of phenol which has an acetamido substituent located meta to the phenolic -OH group. It is a non-toxic regioisomer of paracetamol with analgesic properties, but has never been marketed as a drug.
General Description
Light gray solid.
Air & Water Reactions
Water insoluble.
Reactivity Profile
Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Fire Hazard
Flash point data for 3-ACETAMIDOPHENOL are not available. 3-ACETAMIDOPHENOL is probably combustible.
Purification Methods
Recrystallise the phenol from water. The 3,5-dinitrobenzamide complex gives orange-yellow crystals from hot H2O and has m 212o. [Beilstein 13 H 415, 13 I 132, 13 II 213, 13 III 950, 13 IV 977.]
3-ACETAMIDOPHENOL Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29809 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Alfa Chemistry | info@alfa-chemistry.com | United States | 2344 | 58 | |
| Aston Chemical | 13000000000 | sales@astonchem.com | United States | 1634 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
View Lastest Price from 3-ACETAMIDOPHENOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Metacetamol
621-42-1
|
US $29.00-69.00 / mg | 99.72% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | Metacetamol
621-42-1
|
US $29.00-69.00 / mg | 99.72% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-08-11 | 3-ACETAMIDOPHENOL
621-42-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Metacetamol
621-42-1
- US $29.00-69.00 / mg
- 99.72%
- TargetMol Chemicals Inc.
-
- Metacetamol
621-42-1
- US $29.00-69.00 / mg
- 99.72%
- TargetMol Chemicals Inc.
-
- 3-ACETAMIDOPHENOL
621-42-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd