Aspoxicillin
- CAS No.
- 63358-49-6
- Chemical Name:
- Aspoxicillin
- Synonyms
- ASPC;DOYE;Doyle;TA 058;Aspoxicilin;ASPOXICILLIN;Aspoxicillin (~80%);ASPOXICILLIN 3-HYDRATE;Aspoxicillin USP/EP/BP;N4-Methyl-D-aspariginylamoxicillin
- CBNumber:
- CB1452855
- Molecular Formula:
- C21H27N5O7S
- Molecular Weight:
- 493.53
- MDL Number:
- MFCD01724985
- MOL File:
- 63358-49-6.mol
- MSDS File:
- SDS
Melting point | 195-198° (dec) |
---|---|
Boiling point | 985.1±65.0 °C(Predicted) |
Density | 1.51±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO (Slightly, Sonicated), Methanol (Slightly) |
pka | 2.44±0.50(Predicted) |
form | Solid |
color | White to Off-White |
Water Solubility | Water : 25 mg/mL (50.66 mM; Need ultrasonic) |
Stability | Hygroscopic |
CAS DataBase Reference | 63358-49-6 |
FDA UNII | 0745KNO26J |
ATC code | J01CA19 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26 |
WGK Germany | 3 |
RTECS | MB7548000 |
Aspoxicillin price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | A788675 | Aspoxicillin(~80%) | 63358-49-6 | 50mg | $210 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA167401 | Aspoxicillin | 63358-49-6 | 5mg | $250 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA167401 | Aspoxicillin | 63358-49-6 | 10mg | $300 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA167401 | Aspoxicillin | 63358-49-6 | 25mg | $350 | 2021-12-16 | Buy |
AK Scientific | C991 | Aspoxicillin | 63358-49-6 | 5mg | $387 | 2021-12-16 | Buy |
Aspoxicillin Chemical Properties,Uses,Production
Description
Aspoxicillin is an injectable, amino acid-type penicillin highly active against Gram-positive and Gram-negative bacteria, including the β-lactamase producing Bacillus frugilis. It is reportedly effective in the treatment of peritonitis, pneumonia and bronchitis.
Originator
Tanabe (Japan)
Uses
Aspoxicillin is a broad-spectrum antibiotic.
Definition
ChEBI: Aspoxicillin is a peptide.
Manufacturing Process
1). 3 g (23.6 millimoles) of D-2-amino-3-N-methylcarbamoyl-propionic acid
hydrochloride (D-N'-methylasparagine HCl), 4.5 g of benzyloxycarbonyl
chloride, 30 g of water, 30 ml of tetrahydrofuran and 12 g of potassium
carbonate are mixed at 5° to 10°C. Then, the mixture is stirred at the same
temperature for 2 hours. During the reaction, the mixture is kept at a slightly
alkaline pH (pH 8) with potassium carbonate. 10 ml of water are added to the
reaction mixture, and insoluble materials are filtered off. The filtrate is washed
twice with ethyl acetate, acidified with citric acid and then extracted three
times with 50 ml of ethyl acetate. The ethyl acetate extracts are washed with
water, dried and evaporated to remove solvent. 5.1 g of D-2-
benzyloxycarbonylamino-3-N-methylcarbamoyl-propionic acid are obtained.
MP: 142°-143°C.
2). 2.8 g (10 millimoles) of D-2-benzyloxycarbonylamino-3-Nmethylcarbamoyl-
propionic acid, 2.27 g of dicyclohexylcarbodiimide, 1.27 g of
N-hydroxysuccinimide and 120 ml of tetrahydrofuran are mixed at 0° to 5°C,
and the mixture is stirred at the same temperature for 16 hours. Insoluble
materials are filtered off. Then, the filtrate is evaporated at 20°C under
reduced pressure to remove the solvent, and the crystalline precipitates thus
obtained are washed with a mixture of benzene-ether. 2.6 g of N-(D-2-
benzyloxycarbonylamino-3-N-methylcarbamoyl-propionyloxy)succinimide are
obtained. MP: 132°-134°C.
3). 3.75 g of N-(D-2-benzyloxycarbonylamino-3-Nmethylcarbamoylpropionyloxy)
succinimide are dissolved in 50 ml of
tetrahydrofuran. 12.5 ml of an aqueous 1 N-sodium hydroxide solution
containing 2.3 g of p-hydroxy-D-phenylglycine are added to the solution. The
mixture is stirred at room temperature for 24 hours. 20 ml of ethyl acetate
and 20 ml of water are added to the reaction mixture, and said mixture is
shaken. Then, the aqueous layer is separated, adjusted to pH 3 with citric acid and extracted with a mixture of 20 ml of tetrahydrofuran and 10 ml of ethyl
acetate. The extract is washed with water, dried and evaporated to remove
solvent. The residue thus obtained is washed with ether. 3.0 g of D-2-(D-2-
benzyloxycarbonylamino-3-N-methylcarbamoylpropionamido)- 2-phydroxyphenylacetic
acid are obtained as colorless crystalline powder. MP:
154°-156°C(decomp.).
4). 429 mg of D-2-(D-2-benzyloxycarbonylamino-3-Nmethylcarbamoylpropionamido)-
2-p-hydroxyphenylacetic acid and 382 mg of
6-aminopenicillanic acid triethylamine salt are dissolved in 10 ml of
dimethylformamide. 303 mg of diphenylphosphoric azide [N3PO(OC6H5)2] and
110 mg of triethylamine are added to the solution at -5°C, and the mixture is
stirred at -5°C for 15 hours. After the reaction, the mixture is adjusted to pH
3 with an aqueous 5% citric acid solution and extracted with a mixture of 15
ml of tetrahydrofuran and 10 ml of ethyl acetate. The extract is washed with
water, dried and then evaporated at below 40°C to remove the solvent. Ether
is added to the residue obtained, and precipitates are collected by filtration.
509 mg of 6-[D-2-(D-2-benzyloxycarbonylamino-3-Nmethylcarbamoylpropionamido)-
2-p-hydroxyphenylacetamido]penicillanic acid
are obtained as a colorless powder.
5). 627 mg of 6-[D-2-(D-2-benzyloxycarbonylamino-3-N-methylcarbamoylpropionamido)-
2-p-hydroxyphenylacetamido]penicillanic acid and 400 mg of
30% palladium-BaCO3 are suspended in 10 ml of methanol. The suspension is
shaken at room temperature for 30 minutes. Said shaking step is carried out
in a hydrogen gas atmosphere under atmospheric pressure. After the reaction
is completed, the catalysts are removed by filtration. The filtrate is evaporated
at below 40°C to remove the solvent, and ether is added to the residue. Then,
a colorless crystalline powder is collected by filtration and washed with
tetrahydrofuran. 443 mg of 6-[D-2-(D-2-amino-3-N-methylcarbamoylpropionamido)-
2-p-hydroxyphenylacetamido]penicillanic acid are obtained.
MP: 198°-201°C(decomp.).
brand name
Doyle
Therapeutic Function
Antibiotic
Antimicrobial activity
An acylaminopenicillin, synthesized from amoxicillin. It is
more active than carbenicillin against Ps. aeruginosa and is less
active than piperacillin against Staph. aureus, H. influenzae,
the Enterobacteriaceae and Ps. aeruginosa. It is not absorbed
when dosed orally; the plasma half-life is 87 min after intravenous
infusion.
Aspoxicillin has been used in the treatment of respiratory,
skin and soft tissue and urinary infections in adults and
children, and, in combination with aminoglycosides, against
gynecological infections and infections in patients with hematological
disorders.
Aspoxicillin Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34571 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 8853 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15395 | 58 |
View Lastest Price from Aspoxicillin manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
![]() |
2019-08-08 | Aspoxicillin
63358-49-6
|
US $3.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- Aspoxicillin
63358-49-6
- US $3.00 / KG
- 99%
- Career Henan Chemical Co