Brequinar
- CAS No.
- 96187-53-0
- Chemical Name:
- Brequinar
- Synonyms
- BPQ;CS-157;Brequinar;Biphenquinate;Brequinar (DUP785);Brequinar, 10 mM in DMSO;BREQUINAR;BIPENQUINATE;DUP 785;NSC 368390.;6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl);6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-Methylquinoline-4-carboxyl;6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid
- CBNumber:
- CB01178142
- Molecular Formula:
- C23H15F2NO2
- Molecular Weight:
- 375.37
- MDL Number:
- MFCD00866437
- MOL File:
- 96187-53-0.mol
- MSDS File:
- SDS
| Melting point | 355-357℃ (N,N-dimethylformamide water ) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO:25.9(Max Conc. mg/mL);70.0(Max Conc. mM) |
| form | powder to crystal |
| pka | pKa 4.45(H2O t=RT I=0.10) (Uncertain) |
| color | White to Light yellow |
| CAS DataBase Reference | 96187-53-0 |
| FDA UNII | 5XL19F49H6 |
| NCI Drug Dictionary | brequinar |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933.49.7000 |
Brequinar price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B5707 | Brequinar >98.0%(HPLC) | 96187-53-0 | 20mg | $161 | 2024-03-01 | Buy |
| TCI Chemical | B5707 | Brequinar >98.0%(HPLC) | 96187-53-0 | 100mg | $531 | 2024-03-01 | Buy |
| Cayman Chemical | 24445 | Brequinar ≥98% | 96187-53-0 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 24445 | Brequinar ≥98% | 96187-53-0 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 24445 | Brequinar ≥98% | 96187-53-0 | 10mg | $199 | 2024-03-01 | Buy |
Brequinar Chemical Properties,Uses,Production
Uses
Antineoplastic.
Definition
ChEBI: Brequinar is a quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties. It has a role as an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor, an immunosuppressive agent, an antineoplastic agent, an antiviral agent, a pyrimidine synthesis inhibitor, an anticoronaviral agent and an antimetabolite. It is a member of biphenyls, a member of monofluorobenzenes, a quinolinemonocarboxylic acid and a monocarboxylic acid. It is a conjugate acid of a brequinar(1-).
Biological Activity
Brequinar exhibits anti-neoplastic activity against refractory solid tumors in human and mouse models. Continuous treatment is required for depletion of pyrimidine pools in the cancer cells and tumor inhibition.', 'Brequinar inhibits dihydroorotate dehydrogenase (DHODH), the fourth enzyme in the de novo pyrimidine biosynthesis pathway, preventing the synthesis of DNA and RNA. Brequinar has recently been found to have antiviral activity against a broad spectrum of viruses including flaviviruses (dengue virus, West Nile virus, yellow fever virus, and Powassan virus) and also a plus-strand RNA alphavirus (Western equine encephalitis virus) and a negative-strand RNA rhabdovirus (vesicular stomatitis virus).
Brequinar Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
