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Bazedoxifene

CAS No.
198481-32-2
Chemical Name:
Bazedoxifene
Synonyms
Tse-424;CS-1993;Batoxifene;Bazedoxifen;Bardoxifene;Bazedoxifene;Bazedoxifeno;Unii-Q16tt9C5bk;BAZEDOXIFENE BASE;Bazedoxifene [inn]
CBNumber:
CB01458163
Molecular Formula:
C30H34N2O3
Molecular Weight:
470.6
MDL Number:
MFCD05148441
MOL File:
198481-32-2.mol
MSDS File:
SDS
Last updated:2023-10-31 12:04:19

Bazedoxifene Properties

Melting point 98-102°
Boiling point 694.4±55.0 °C(Predicted)
Density 1.19
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka 10.12±0.15(Predicted)
color White to Very Dark Beige
FDA UNII Q16TT9C5BK
NCI Drug Dictionary bazedoxifene
ATC code G03XC02

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H360
Precautionary statements  P201-P202-P281-P308+P313-P405-P501

Bazedoxifene price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B129245 Bazedoxifene 198481-32-2 25mg $790 2021-12-16 Buy
ApexBio Technology A3232 Bazedoxifene 198481-32-2 5mg $142 2021-12-16 Buy
ApexBio Technology A3232 Bazedoxifene 198481-32-2 10mg $249 2021-12-16 Buy
American Custom Chemicals Corporation API0024680 BAZEDOXIFENE 95.00% 198481-32-2 5MG $502.94 2021-12-16 Buy
Ambeed A696565 Bazedoxifene 98+% 198481-32-2 5mg $109 2021-12-16 Buy
Product number Packaging Price Buy
B129245 25mg $790 Buy
A3232 5mg $142 Buy
A3232 10mg $249 Buy
API0024680 5MG $502.94 Buy
A696565 5mg $109 Buy

Bazedoxifene Chemical Properties,Uses,Production

Uses

Bazedoxifene is an nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene is used as an antiosteoporotic.

Definition

ChEBI: Bazedoxifene is a phenylindole.

General Description

Bazedoxifene, 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol (Viviant), was declared to be “approvable” bythe FDA in 2007 for the prevention of postmenopausalosteoporosis. As of mid-2009, final approval in the UnitedStates is still pending. Bazedoxifene was approved inEurope in 2009 for the treatment of post–menopausalosteoporosis.

Clinical Use

Bazedoxifene is an indole-based SERM that is under investigation for the treatment and prevention of postmenopausal osteoporosis. It also is being evaluated in combination with Premarin (conjugated estrogens). Bazedoxifene displaces 17β-estradiol from estrogen receptors and has excellent binding affinity for the receptor itself. Unlike raloxifene, this agent does not cause hot flashes at the doses required to have a beneficial effect on bone. In addition, it does not cause uterine or mammary gland stimulation.

Enzyme inhibitor

This potent and selective estrogen receptor modulator, or SERM (FW = 530.65 g/mol; CAS 198481-33-3; Solubility: 00 mM in DMSO), also named 1-[[4-[2- (hexahydro-1H-azepin-1-yl) ethoxy]phenyl]methyl]-2- (4- hydroxyphenyl) -3-methyl-1H-indol-5-ol, selectivity targets the extrogen receptor ERα (IC50 = 26 nM), with weaker action against ERβ (IC50 = 99 nM), inhibiting 17β-estradiol-induced proliferation of MCF-7 cells. Bazedoxifene represents a promising new treatment for osteoporosis, one with a potential for less uterine and vasomotor effects than selective estrogen receptor modulators now used clinically.

target

estrogen receptor

198480-21-6
198481-32-2
Synthesis of Bazedoxifene from 1-[4-(2-AZEPAN-1-YL-ETHOXY)-BENZYL]-5-BENZYLOXY-2-(4-BENZYLOXY-PHENYL)-3-METHYL-1H-INDOLE
Global( 123)Suppliers
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Alfa Chemistry
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InvivoChem
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View Lastest Price from Bazedoxifene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Bazedoxifene pictures 2024-09-25 Bazedoxifene
198481-32-2
US $0.00 / KG 1KG 99% 20 TONS Wuhan Senwayer Century Chemical Co.,Ltd
Bazedoxifene  pictures 2024-08-27 Bazedoxifene
198481-32-2
US $85.00-850.00 / kg 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
Bazedoxifene pictures 2019-09-19 Bazedoxifene
198481-32-2
US $1.00 / KG 1KG 98% 100KG Career Henan Chemical Co
  • Bazedoxifene pictures
  • Bazedoxifene
    198481-32-2
  • US $0.00 / KG
  • 99%
  • Wuhan Senwayer Century Chemical Co.,Ltd
  • Bazedoxifene  pictures
  • Bazedoxifene
    198481-32-2
  • US $85.00-850.00 / kg
  • 0.99
  • Zibo Hangyu Biotechnology Development Co., Ltd
  • Bazedoxifene pictures
  • Bazedoxifene
    198481-32-2
  • US $1.00 / KG
  • 98%
  • Career Henan Chemical Co
1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-indol-5-ol 1-((4-(2-Hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol 1H-Indol-5-ol, 1-((4-(2-(hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl- Bazedoxifene Bazedoxifene [inn] Bazedoxifeno Bazedoxifeno [inn-spanish] Tse-424 Unii-Q16tt9C5bk Bazedoxifen CS-1993 Batoxifene BAZEDOXIFENE BASE Bazedoxifene free base 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphen... 1-(4-(2-(Azepan-1-yl)ethoxy)benzyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol Bardoxifene 198481-32-2 C30H34N2O3 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals