Bazedoxifene
- CAS No.
- 198481-32-2
- Chemical Name:
- Bazedoxifene
- Synonyms
- Tse-424;CS-1993;Batoxifene;Bazedoxifen;Bazedoxifene;Bazedoxifeno;Unii-Q16tt9C5bk;BAZEDOXIFENE BASE;Bazedoxifene [inn];Bazedoxifene free base
- CBNumber:
- CB01458163
- Molecular Formula:
- C30H34N2O3
- Molecular Weight:
- 470.6
- MDL Number:
- MFCD05148441
- MOL File:
- 198481-32-2.mol
- MSDS File:
- SDS
| Melting point | 98-102° |
|---|---|
| Boiling point | 694.4±55.0 °C(Predicted) |
| Density | 1.19 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 10.12±0.15(Predicted) |
| color | White to Very Dark Beige |
| FDA UNII | Q16TT9C5BK |
| NCI Drug Dictionary | bazedoxifene |
| ATC code | G03XC02 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
Bazedoxifene price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B129245 | Bazedoxifene | 198481-32-2 | 25mg | $790 | 2021-12-16 | Buy |
| ApexBio Technology | A3232 | Bazedoxifene | 198481-32-2 | 5mg | $142 | 2021-12-16 | Buy |
| ApexBio Technology | A3232 | Bazedoxifene | 198481-32-2 | 10mg | $249 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0024680 | BAZEDOXIFENE 95.00% | 198481-32-2 | 5MG | $502.94 | 2021-12-16 | Buy |
| Ambeed | A696565 | Bazedoxifene 98+% | 198481-32-2 | 5mg | $109 | 2021-12-16 | Buy |
Bazedoxifene Chemical Properties,Uses,Production
Uses
Bazedoxifene is an nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene is used as an antiosteoporotic.
Definition
ChEBI: Bazedoxifene is a phenylindole.
General Description
Bazedoxifene, 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol (Viviant), was declared to be “approvable” bythe FDA in 2007 for the prevention of postmenopausalosteoporosis. As of mid-2009, final approval in the UnitedStates is still pending. Bazedoxifene was approved inEurope in 2009 for the treatment of post–menopausalosteoporosis.
Clinical Use
Bazedoxifene is an indole-based SERM that is under investigation for the treatment and prevention of postmenopausal osteoporosis. It also is being evaluated in combination with Premarin (conjugated estrogens). Bazedoxifene displaces 17β-estradiol from estrogen receptors and has excellent binding affinity for the receptor itself. Unlike raloxifene, this agent does not cause hot flashes at the doses required to have a beneficial effect on bone. In addition, it does not cause uterine or mammary gland stimulation.
Enzyme inhibitor
This potent and selective estrogen receptor modulator, or SERM (FW = 530.65 g/mol; CAS 198481-33-3; Solubility: 00 mM in DMSO), also named 1-[[4-[2- (hexahydro-1H-azepin-1-yl) ethoxy]phenyl]methyl]-2- (4- hydroxyphenyl) -3-methyl-1H-indol-5-ol, selectivity targets the extrogen receptor ERα (IC50 = 26 nM), with weaker action against ERβ (IC50 = 99 nM), inhibiting 17β-estradiol-induced proliferation of MCF-7 cells. Bazedoxifene represents a promising new treatment for osteoporosis, one with a potential for less uterine and vasomotor effects than selective estrogen receptor modulators now used clinically.
target
estrogen receptor
Bazedoxifene Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10986 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10319 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15352 | 58 |
| ChemExpress | +86-021-58950125 +86-021-58950125; | info@chemexpress.com | China | 737 | 58 |
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Supplier | Advantage |
|---|---|
| Zibo Hangyu Biotechnology Development Co., Ltd | 58 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| career henan chemical co | 58 |
| Biochempartner | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 58 |
| Hubei Ipure Biology Co., Ltd | 58 |
| AFINE CHEMICALS LIMITED | 58 |
| ChemExpress | 58 |
| Alfa Chemistry | 58 |
| InvivoChem | 58 |
View Lastest Price from Bazedoxifene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-09-25 | Bazedoxifene
198481-32-2
|
US $0.00 / KG | 1KG | 99% | 20 TONS | Wuhan Senwayer Century Chemical Co.,Ltd | |
 |
2024-08-27 | Bazedoxifene
198481-32-2
|
US $85.00-850.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2019-09-19 | Bazedoxifene
198481-32-2
|
US $1.00 / KG | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- Bazedoxifene
198481-32-2
- US $0.00 / KG
- 99%
- Wuhan Senwayer Century Chemical Co.,Ltd
-
- Bazedoxifene
198481-32-2
- US $85.00-850.00 / kg
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- Bazedoxifene
198481-32-2
- US $1.00 / KG
- 98%
- Career Henan Chemical Co