Canertinib
- CAS No.
- 267243-28-7
- Chemical Name:
- Canertinib
- Synonyms
- CS-152;PD-183805;Canetinib;Canertinib base;quinazolin-6-yl);CI-1033; PD-183805;CI-1033(Canertinib);Canertinib (CI-1033);Canertinib USP/EP/BP;-7-(3-morpholinopropoxy)
- CBNumber:
- CB01458390
- Molecular Formula:
- C24H25ClFN5O3
- Molecular Weight:
- 485.94
- MDL Number:
- MFCD09837878
- MOL File:
- 267243-28-7.mol
- MSDS File:
- SDS
| Melting point | 188-190° |
|---|---|
| Boiling point | 691.0±55.0 °C(Predicted) |
| Density | 1.355±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | insoluble in H2O; ≥10.1 mg/mL in EtOH; ≥12.15 mg/mL in DMSO with gentle warming |
| pka | 12.09±0.43(Predicted) |
| form | Yellow powder. |
| color | Light yellow to yellow |
| CAS DataBase Reference | 267243-28-7 |
| FDA UNII | C78W1K5ASF |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Canertinib price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C175600 | Canertinib | 267243-28-7 | 10mg | $65 | 2021-12-16 | Buy |
| ChemScene | CS-0121 | Canertinib 98.02% | 267243-28-7 | 100mg | $137 | 2021-12-16 | Buy |
| AK Scientific | Y0252 | Canertinib | 267243-28-7 | 25mg | $170 | 2021-12-16 | Buy |
| ApexBio Technology | A1845 | Canertinib(CI-1033) | 267243-28-7 | 10mg | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A1845 | Canertinib(CI-1033) | 267243-28-7 | 10mM(in 1mL DMSO) | $50 | 2021-12-16 | Buy |
Canertinib Chemical Properties,Uses,Production
Uses
Antineoplastic; irreversible pan-erbB tyrosine kinase inhibitor used to treat cancer.
Uses
CI-1033 is a potent inhibitor of EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.
Uses
Canertinib is a kind of irreversible pan-erbB tyrosine kinase inhibitor used to treat cancer.
Definition
ChEBI: A quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a propenamido group at the 6-position, and a 3-morpholinopropoxy group at the 7-position.
Biological Activity
canertinib (also known as ci-1033), a 3-chloro, 4-fluoro, 4-anilinoquinazoline, is an orally available, potent and irreversible pan-erbb tyrosine kinase inhibitor that inhibits egfr, her2 and her4 in vitro with the half maximal inhibition concentration ic50 of 0.8 nm, 19 nm and 7 nm respectively [1].canertinib irreversibly binds into the atp pocket within the tk domain of all erbb family members, where the acrylamide side-chain at position c6 of canertinib is brought into close proximity with cysteines of erbb members, followed by the rapid formation of a covalent bond, which permanently inactivates the catalytically active erb1, erb2 and erb4 family members and effectively inhibits erbb3-dependent signaling [2].
References
[1] michelle arkin, mark m. moasser. her2 directed small molecule antagonists. curr opin investig drugs. author manuscript; available in pmc 2011 february 1. published in final edited form as: curr opin investig drugs. 2008 december; 9(12): 1264–1276.
[2] calvo e, tolcher aw, hammond la, patnaik a, de bono js, eiseman ia, olson sc, lenehan pf, mccreery h, lorusso p, rowinsky ek. administration of ci-1033, an irreversible pan-erbb tyrosine kinase inhibitor, is feasible on a 7-day on, 7-day off schedule: a phase i pharmacokinetic and food effect study. clin cancer res. 2004 nov 1;10(21):7112-20.
Canertinib Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5857 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 340 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
View Lastest Price from Canertinib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-21 | Canertinib
267243-28-7
|
US $0.00-0.00 / kg | 1kg | 99% | 20tons | Sinoway Industrial co., ltd. | |
 |
2024-11-19 | Canertinib
267243-28-7
|
US $79.00-50.00 / mg | 99.18% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-10-25 | Canertinib
267243-28-7
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. |
-
- Canertinib
267243-28-7
- US $0.00-0.00 / kg
- 99%
- Sinoway Industrial co., ltd.
-
- Canertinib
267243-28-7
- US $79.00-50.00 / mg
- 99.18%
- TargetMol Chemicals Inc.
-
- Canertinib
267243-28-7
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.