AG 18
- CAS No.
- 118409-57-7
- Chemical Name:
- AG 18
- Synonyms
- AG 18;TX 825;CS-931;RG-50810;RG 50858;AG18, >=98%;TYRPHOSTIN 23;TYRPHOSTIN A23;Tyrphostin AG 1;AG-18(RG-50810)
- CBNumber:
- CB2358507
- Molecular Formula:
- C10H6N2O2
- Molecular Weight:
- 186.17
- MDL Number:
- MFCD00133899
- MOL File:
- 118409-57-7.mol
- MSDS File:
- SDS
Melting point | 225°C |
---|---|
Boiling point | 421.1±45.0 °C(Predicted) |
Density | 1.428±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Soluble in DMSO, ethanol, or DMF |
pka | 7.26±0.18(Predicted) |
form | Yellow solid |
color | Yellow |
λmax | 464nm(DMSO)(lit.) |
Stability | Store in refrigerator |
FDA UNII | RV0GCD31OJ |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS08 |
---|---|
Signal word | Warning |
Hazard statements | H371-H373 |
Precautionary statements | P501-P260-P270-P264-P308+P311-P405 |
WGK Germany | 3 |
HS Code | 2926.90.5050 |
AG 18 price More Price(33)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | T7165 | Tyrphostin 23 ≥98% | 118409-57-7 | 5mg | $130 | 2024-03-01 | Buy |
Sigma-Aldrich | 658395 | AG 18 A broad-spectrum protein tyrosine kinase inhibitor. | 118409-57-7 | 5mg | $85.2 | 2024-03-01 | Buy |
TCI Chemical | T3503 | Tyrphostin A23 >98.0%(GC) | 118409-57-7 | 25mg | $128 | 2022-04-27 | Buy |
TCI Chemical | T3503 | Tyrphostin A23 >98.0%(GC) | 118409-57-7 | 100mg | $280 | 2024-03-01 | Buy |
Alfa Aesar | J60308 | Tyrphostin A23, 99% | 118409-57-7 | 5mg | $73.65 | 2024-03-01 | Buy |
AG 18 Chemical Properties,Uses,Production
Chemical Properties
Yellow Powder
Uses
A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM).
Uses
AG 18 inhibits EGFR with IC50 of 35 μM.
Definition
ChEBI: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile is a member of catechols.
Biological Activity
Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.
Biochem/physiol Actions
Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
AG 18 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29892 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24330 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52861 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
View Lastest Price from AG 18 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2019-09-06 | (3,4-Dihydroxybenzylidene)-malononitrile
118409-57-7
|
US $1.00 / KG | 1KG | 98% | 20kg | Career Henan Chemical Co |
-
- (3,4-Dihydroxybenzylidene)-malononitrile
118409-57-7
- US $1.00 / KG
- 98%
- Career Henan Chemical Co