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| | AG 18 Chemical Properties |
| Melting point | 225°C | | Boiling point | 421.1±45.0 °C(Predicted) | | density | 1.428±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO, ethanol, or DMF | | pka | 7.26±0.18(Predicted) | | form | Yellow solid | | color | Yellow | | λmax | 464nm(DMSO)(lit.) | | Stability: | Store in refrigerator |
| WGK Germany | 3 | | HS Code | 2926.90.5050 |
| | AG 18 Usage And Synthesis |
| Chemical Properties | Yellow Powder | | Uses | A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM). | | Uses | AG 18 inhibits EGFR with IC50 of 35 μM. | | Definition | ChEBI: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile is a member of catechols. | | Biological Activity | Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling. | | Biochem/physiol Actions | Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,. |
| | AG 18 Preparation Products And Raw materials |
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