NS-398
- CAS No.
- 123653-11-2
- Chemical Name:
- NS-398
- Synonyms
- NS NS;NS-398;CS-2231;NS-398 98%;Taisho NS 398;NS-398 (NS 398;NS-398 USP/EP/BP;NS-398 - CAS 123653-11-2 - Calbiochem;Inhibitor,inhibit,NS-398,NS 398,COX,Cyclooxygenase;N-[2-(cyclohexoxy)-4-nitro-phenyl]methanesulfonamide
- CBNumber:
- CB1754593
- Molecular Formula:
- C13H18N2O5S
- Molecular Weight:
- 314.36
- MDL Number:
- MFCD00882995
- MOL File:
- 123653-11-2.mol
- MSDS File:
- SDS
Melting point | 124-126 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) |
---|---|
Boiling point | 490.6±55.0 °C(Predicted) |
Density | 1.377±0.06 g/cm3(Predicted) |
RTECS | PB0473500 |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO: >5 mg/mL |
pka | 6.33±0.10(Predicted) |
form | solid |
color | off-white |
FDA UNII | 9SP55KM2KS |
SAFETY
Risk and Safety Statements
Safety Statements | 22-24/25 |
---|---|
WGK Germany | 3 |
HS Code | 2935.90.9500 |
NS-398 price More Price(48)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | N194 | NS-398 ≥98% (HPLC), solid | 123653-11-2 | 5mg | $110.4 | 2024-03-01 | Buy |
Sigma-Aldrich | 349254 | NS-398 A cell-permeable selective inhibitor of COX-2 | 123653-11-2 | 5mg | $216 | 2024-03-01 | Buy |
TCI Chemical | N1152 | NS-398 | 123653-11-2 | 10MG | $113 | 2024-03-01 | Buy |
TCI Chemical | N1152 | NS-398 | 123653-11-2 | 50MG | $411 | 2024-03-01 | Buy |
Alfa Aesar | J67313 | NS-398, 98% | 123653-11-2 | 5mg | $97.1 | 2023-06-20 | Buy |
NS-398 Chemical Properties,Uses,Production
Description
NS-
Uses
NS-398 is a selective Cox-2 inhibitor neuroprotective agent.
Definition
ChEBI: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
Biological Activity
Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and > 100 μ M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo .
storage
Store at RT
References
[1]. futaki n, takahashi s, yokoyama m, et al. ns-398, a new anti-inflammatory agent, selectively inhibits prostaglandin g/h synthase/cyclooxygenase (cox-2) activity in vitro. prostaglandins, 1994, 47(1): 55-59.
[2]. elder dj, halton de, crew te, et al. apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug ns-398. int j cancer, 2000, 86(4): 553-560.
[3]. mack strong ve, mackrell pj, concannon em, et al. ns-398 treatment after trauma modifies nf-kappab activation and improves survival. j surg res, 2001, 98(1): 40-46.
NS-398 Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12450 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 973 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24330 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +8619930503259 | cherry@crovellbio.com | China | 18430 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from NS-398 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-21 | NS-398
123653-11-2
|
US $50.00 / kg | 1kg | 99% | 1000 | hebei hongtan Biotechnology Co., Ltd | |
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2024-08-15 | NS-398
123653-11-2
|
US $20.00-1.00 / kg | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. | |
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2023-12-04 | NS-398
123653-11-2
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |