LAVENDUSTIN A
- CAS No.
- 125697-92-9
- Chemical Name:
- LAVENDUSTIN A
- Synonyms
- RG14355;NSC 678027;LAVENDUSTIN A;Lavendustin A,98%;RG-14355;NSC 678027;LAVENDUSTIN A USP/EP/BP;Lavendustin A - CAS 125697-92-9 - Calbiochem;5-AMINO-[(N-2,5-DIHYDROXYBENZYL)-N'-2-HYDROXYBENZYL]SALICYLIC ACID;5-[(2,5-Dihydroxybenzyl)(2-hydroxybenzyl)amino]-2-hydroxybenzoic acid;5-[[(2,5-DIHYDROXYPHENYL)METHYL][(2-HYDROXYPHENYL)METHYL]AMINO]-2-HYDROXYBENZOIC ACID
- CBNumber:
- CB2135704
- Molecular Formula:
- C21H19NO6
- Molecular Weight:
- 381.38
- MDL Number:
- MFCD00153822
- MOL File:
- 125697-92-9.mol
Melting point | 205-215 °C |
---|---|
Boiling point | 741.7±60.0 °C(Predicted) |
Density | 1.495±0.06 g/cm3(Predicted) |
RTECS | DG8578950 |
storage temp. | −20°C |
solubility | DMSO: soluble |
pka | 2.31±0.10(Predicted) |
form | crystalline |
color | Yellow to brown |
Sensitive | Air Sensitive |
Stability | Moisture Sensitive: Hygroscopic |
CAS DataBase Reference | 125697-92-9(CAS DataBase Reference) |
FDA UNII | 3Y0G32G2RV |
LAVENDUSTIN A price More Price(20)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 428150 | Lavendustin A | 125697-92-9 | 1mg | $216 | 2024-03-01 | Buy |
Alfa Aesar | J67494 | Lavendustin A | 125697-92-9 | 1mg | $171 | 2021-12-16 | Buy |
Cayman Chemical | 10010268 | Lavendustin A ≥95% | 125697-92-9 | 1mg | $81 | 2024-03-01 | Buy |
Cayman Chemical | 10010268 | Lavendustin A ≥95% | 125697-92-9 | 5mg | $179 | 2024-03-01 | Buy |
Cayman Chemical | 10010268 | Lavendustin A ≥95% | 125697-92-9 | 10mg | $317 | 2024-03-01 | Buy |
LAVENDUSTIN A Chemical Properties,Uses,Production
Description
Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 μM). It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis.
Chemical Properties
Off-White Solid
Uses
A potent tyrosine kinase inhibitor. Inhibition is competitive with ATP and is noncompetitive with the peptide.
Definition
ChEBI: 5-[(2,5-dihydroxyphenyl)methyl-[(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid is an aromatic amine.
Biological Activity
Potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 11 nM). Inhibits p60 c-src with an IC 50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC 50 > 100 μ M).
target
EGFR | PKC | PI3K | Calcium Channel
LAVENDUSTIN A Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24099 | 58 |
Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
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