LAVENDUSTIN A

LAVENDUSTIN A 구조식 이미지
카스 번호:
125697-92-9
상품명:
LAVENDUSTIN A
동의어(영문):
RG14355;NSC 678027;LAVENDUSTIN A;Lavendustin A,98%;RG-14355;NSC 678027;LAVENDUSTIN A USP/EP/BP;Lavendustin A - CAS 125697-92-9 - Calbiochem;5-AMINO-[(N-2,5-DIHYDROXYBENZYL)-N'-2-HYDROXYBENZYL]SALICYLIC ACID;5-[(2,5-Dihydroxybenzyl)(2-hydroxybenzyl)amino]-2-hydroxybenzoic acid;5-[[(2,5-DIHYDROXYPHENYL)METHYL][(2-HYDROXYPHENYL)METHYL]AMINO]-2-HYDROXYBENZOIC ACID
CBNumber:
CB2135704
분자식:
C21H19NO6
포뮬러 무게:
381.38
MOL 파일:
125697-92-9.mol
MSDS 파일:
SDS

LAVENDUSTIN A 속성

녹는점
205-215 °C
끓는 점
741.7±60.0 °C(Predicted)
밀도
1.495±0.06 g/cm3(Predicted)
RTECS 번호
DG8578950
저장 조건
−20°C
용해도
DMSO: 용해될 수 있다
산도 계수 (pKa)
2.31±0.10(Predicted)
물리적 상태
수정 같은
색상
노란색에서 갈색으로
감도
Air Sensitive
안정성
습기에 민감한: 흡습성
CAS 데이터베이스
125697-92-9(CAS DataBase Reference)

안전

위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 37/39-26
WGK 독일 3
HS 번호 29225000

LAVENDUSTIN A C화학적 특성, 용도, 생산

개요

Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 μM). It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis.

화학적 성질

Off-White Solid

생물학적 활성

Potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 11 nM). Inhibits p60 c-src with an IC 50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC 50 > 100 μ M).

LAVENDUSTIN A 준비 용품 및 원자재

원자재

준비 용품


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