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Prostratin, PKC activator

Prostratin, PKC activator Structure
Prostratin, PKC activator structure
CAS No.
60857-08-1
Chemical Name:
Prostratin, PKC activator
Synonyms
SA 101A;NSC 623310;CCRIS 6292;PROSTRATIN;Prostatin >99%;Stillingia Facto;13-O-Acetylphorbol;Prostratin, PKC activator;12-DEOXYPHORBOL 13-ACETATE;13-O-Acetyl-12-deoxyphorbol
CBNumber:
CB0150130
Molecular Formula:
C22H30O6
Molecular Weight:
390.47
MDL Number:
MFCD00674138
MOL File:
60857-08-1.mol
MSDS File:
SDS
Last updated:2024-10-23 13:36:13
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Prostratin, PKC activator Properties

Melting point 216-219℃
Boiling point 550.5±50.0 °C(Predicted)
Density 1.31
storage temp. -20°C
solubility Soluble in DMSO at 30mg/ml
form white powder
pka 11.40±0.70(Predicted)
color Off-white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
FDA UNII KO94U6DIQ6

SAFETY

Risk and Safety Statements

WGK Germany  3
HS Code  2916200090

Prostratin, PKC activator price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P0077 Prostratin ≥98% (HPLC) 60857-08-1 1mg $127 2024-03-01 Buy
Sigma-Aldrich P0077 Prostratin ≥98% (HPLC) 60857-08-1 5mg $308.4 2024-03-01 Buy
Alfa Aesar J60971 Prostratin, 99+% 60857-08-1 1mg $163 2023-06-20 Buy
Alfa Aesar J60971 Prostratin, 99+% 60857-08-1 5mg $626 2023-06-20 Buy
Cayman Chemical 10272 Prostratin ≥98% 60857-08-1 500μg $68 2024-03-01 Buy
Product number Packaging Price Buy
P0077 1mg $127 Buy
P0077 5mg $308.4 Buy
J60971 1mg $163 Buy
J60971 5mg $626 Buy
10272 500μg $68 Buy

Prostratin, PKC activator Chemical Properties,Uses,Production

Description

Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells with an IC50 value of ~0.5 μM. Originally, prostratin was isolated from plant sources including P. prostrata, E. cornigera, and H. nutans. The effects of prostratin are mediated through activation of NF-κB via protein kinase C and by downregulation of HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5.

Uses

Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells . [Cayman Chemical]

Definition

ChEBI: A natural product found in Euphorbia fischeriana.

Biochem/physiol Actions

Prostratin, an unusual non-tumorigenic phorbol ester, is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases). Prostratin exhibits potent in vitro activity by inducing HIV expression in latently infected cell lines and primary cells, thus antagonizing HIV latency. Activation of PKC and NF-kB has been proposed as the mechanism of action. Prostratin also inhibits HIV entry into target cells by down-regulating CD4 and CXCR4 receptors.

References

1) Cashmore et al. (1976), The structure of prostratin: a toxic tetracyclic diterpene ester from Pimelea Prostrata; Tetrahedron Lett., 17 1737 2) Miana et al. (2015), Prostratin: An Overview; Mini Rev. Med. Chem., 15 1122 3) Shen et al. (2015), The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents; Cancer Lett., 356 (2 Pt. B) 686 4) Biancotto et al. (2004), Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue; J. Virol., 78 10507 5) Geribaldi-Doldan et al. (2015), 12-Deoxyphorbols Promote Adult Neurogenesis by Inducing Neural Progenitor Cell Proliferation via PKC activation ; Int. J, Neuropsychopharmacol., 19 pyv085

Prostratin, PKC activator Preparation Products And Raw materials

Raw materials

Preparation Products

Prostratin, PKC activator Suppliers

Global( 63)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2472 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18644 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29815 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32063 58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		+8617735180244 mike_yan@xuanranglobal.com CHINA 4017 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 23225 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
Henan Bao Enluo International TradeCo.，LTD 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Hubei xin bonus chemical co. LTD 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		58
Dideu Industries Group Limited 		58
LEAPCHEM CO., LTD. 		58
Aladdin Scientific 		58
J & K SCIENTIFIC LTD. 76

View Lastest Price from Prostratin, PKC activator manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Prostratin pictures 2024-10-24 Prostratin
60857-08-1
 US $1080.00-1960.00 / mg 10g TargetMol Chemicals Inc.
Prostratin pictures 2023-08-04 Prostratin
60857-08-1
 US $10.00 / kg 1kg 99% 500t/month Henan Bao Enluo International TradeCo.，LTD
Prostratin, PKC activator pictures 2020-02-19 Prostratin, PKC activator
60857-08-1
 US $7.00 / KG 1KG 99% 100kg Career Henan Chemical Co
  • Prostratin pictures
  • Prostratin
    60857-08-1
  • US $1080.00-1960.00 / mg
  • TargetMol Chemicals Inc.
  • Prostratin pictures
  • Prostratin
    60857-08-1
  • US $10.00 / kg
  • 99%
  • Henan Bao Enluo International TradeCo.，LTD

60857-08-1(Prostratin, PKC activator)Related Search:

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SA 101A Prostatin >99% 12-Deoxyphorbol 13-Acetate, dPAc (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a -decahydro-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl- 13-O-Acetyl-12-deoxyphorbol PROSTRATIN (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a -decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl- 5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 13-O-Acetylphorbol NSC 623310 Stillingia Facto CCRIS 6292 12-DEOXYPHORBOL 13-ACETATE (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aβ,7bα-dihydroxy-9aα-acetoxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benzo[1,2-e]azulene-5-one (1aR)-9aα-Acetoxy-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα-dihydroxy-3-hydroxymethyl-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one Prostratin, PKC activator 5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, (1aR,1bS,4aR,7aS,7bR,8R,9aS)- Prostratin, PKC activator USP/EP/BP (1aR,1bS,4aR,7aS,7bR,8R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl acetate 60857-08-1 Activator Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase Inhibitors and Activators