Prostratin, PKC activator

Prostratin, PKC activator Properties

Melting point	216-219℃
Boiling point	550.5±50.0 °C(Predicted)
Density	1.31
storage temp.	-20°C
solubility	Soluble in DMSO at 30mg/ml
form	white powder
pka	11.40±0.70(Predicted)
color	Off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
FDA UNII	KO94U6DIQ6

SAFETY

Risk and Safety Statements

WGK Germany	3
HS Code	2916200090

Prostratin, PKC activator price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P0077	Prostratin ≥98% (HPLC)	60857-08-1	1mg	$127	2024-03-01	Buy
Sigma-Aldrich	P0077	Prostratin ≥98% (HPLC)	60857-08-1	5mg	$308.4	2024-03-01	Buy
Alfa Aesar	J60971	Prostratin, 99+%	60857-08-1	1mg	$163	2023-06-20	Buy
Alfa Aesar	J60971	Prostratin, 99+%	60857-08-1	5mg	$626	2023-06-20	Buy
Cayman Chemical	10272	Prostratin ≥98%	60857-08-1	500μg	$68	2024-03-01	Buy

Product number	Packaging	Price	Buy
P0077	1mg	$127	Buy
P0077	5mg	$308.4	Buy
J60971	1mg	$163	Buy
J60971	5mg	$626	Buy
10272	500μg	$68	Buy

Prostratin, PKC activator Chemical Properties,Uses,Production

Description

Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells with an IC₅₀ value of ~0.5 μM. Originally, prostratin was isolated from plant sources including P. prostrata, E. cornigera, and H. nutans. The effects of prostratin are mediated through activation of NF-κB via protein kinase C and by downregulation of HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5.

Uses

Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells . [Cayman Chemical]

Definition

ChEBI: A natural product found in Euphorbia fischeriana.

Biochem/physiol Actions

Prostratin, an unusual non-tumorigenic phorbol ester, is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases). Prostratin exhibits potent in vitro activity by inducing HIV expression in latently infected cell lines and primary cells, thus antagonizing HIV latency. Activation of PKC and NF-kB has been proposed as the mechanism of action. Prostratin also inhibits HIV entry into target cells by down-regulating CD4 and CXCR4 receptors.

References

1) Cashmore et al. (1976), The structure of prostratin: a toxic tetracyclic diterpene ester from Pimelea Prostrata; Tetrahedron Lett., 17 1737 2) Miana et al. (2015), Prostratin: An Overview; Mini Rev. Med. Chem., 15 1122 3) Shen et al. (2015), The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents; Cancer Lett., 356 (2 Pt. B) 686 4) Biancotto et al. (2004), Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue; J. Virol., 78 10507 5) Geribaldi-Doldan et al. (2015), 12-Deoxyphorbols Promote Adult Neurogenesis by Inducing Neural Progenitor Cell Proliferation via PKC activation ; Int. J, Neuropsychopharmacol., 19 pyv085

Prostratin, PKC activator Preparation Products And Raw materials

Raw materials

Preparation Products

Prostratin, PKC activator Suppliers

Global( 63)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18779	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	+8617735180244	mike_yan@xuanranglobal.com	CHINA	4017	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22883	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76

Supplier	Advantage
Henan Bao Enluo International TradeCo.，LTD	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Hubei xin bonus chemical co. LTD	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	58
Dideu Industries Group Limited	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
J & K SCIENTIFIC LTD.	76

View Lastest Price from Prostratin, PKC activator manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-10-24	Prostratin 60857-08-1	US $1080.00-1960.00 / mg			10g	TargetMol Chemicals Inc.
2023-08-04	Prostratin 60857-08-1	US $10.00 / kg	1kg	99%	500t/month	Henan Bao Enluo International TradeCo.，LTD
2020-02-19	Prostratin, PKC activator 60857-08-1	US $7.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

Prostratin
60857-08-1
US $1080.00-1960.00 / mg
TargetMol Chemicals Inc.

Prostratin
60857-08-1
US $10.00 / kg
99%
Henan Bao Enluo International TradeCo.，LTD

Prostratin, PKC activator
60857-08-1
US $7.00 / KG
99%
Career Henan Chemical Co

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SA 101A Prostatin >99% 12-Deoxyphorbol 13-Acetate, dPAc (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a -decahydro-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl- 13-O-Acetyl-12-deoxyphorbol PROSTRATIN (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a -decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl- 5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 13-O-Acetylphorbol NSC 623310 Stillingia Facto CCRIS 6292 12-DEOXYPHORBOL 13-ACETATE (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aβ,7bα-dihydroxy-9aα-acetoxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benzo[1,2-e]azulene-5-one (1aR)-9aα-Acetoxy-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα-dihydroxy-3-hydroxymethyl-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one Prostratin, PKC activator 5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, (1aR,1bS,4aR,7aS,7bR,8R,9aS)- Prostratin, PKC activator USP/EP/BP (1aR,1bS,4aR,7aS,7bR,8R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl acetate 60857-08-1 Activator Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase Inhibitors and Activators