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LY 341495

CAS No.
201943-63-7
Chemical Name:
LY 341495
Synonyms
CS-416;LY 341495;LY 341495;LY-341495;9H-Xanthene-9-propanoic acid, α-amino-α-[(1S,2S)-2-carboxycyclopropyl]-, (αS)-;(2S)-2-AMINO-2-[(1S,2S)-2-CARBOXYCYCLOPROP-1-YL]-3-(XANTH-9-YL) PROPANOIC ACID;(alphaS)-alpha-Amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid;(1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic acid;(alphaS)-alpha-Amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid LY 341495
CBNumber:
CB0200679
Molecular Formula:
C20H19NO5
Molecular Weight:
353.37
MDL Number:
MFCD00949707
MOL File:
201943-63-7.mol
Last updated:2024-07-02 08:54:57

LY 341495 Properties

Boiling point 580.8±40.0 °C(Predicted)
Density 1.432
storage temp. Store at RT
solubility Limited solubility, soluble in DMSO
form crystalline solid
pka 2.02±0.10(Predicted)
color White to off-white
FDA UNII AQ73SP6QSF

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

LY 341495 price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 14693 LY341495 ≥98% 201943-63-7 1mg $44 2024-03-01 Buy
Cayman Chemical 14693 LY341495 ≥98% 201943-63-7 10mg $183 2024-03-01 Buy
Cayman Chemical 14693 LY341495 ≥98% 201943-63-7 50mg $745 2024-03-01 Buy
Tocris 1209 LY341495 ≥98%(HPLC) 201943-63-7 50 $1092 2021-12-16 Buy
Tocris 1209 LY341495 ≥98%(HPLC) 201943-63-7 1 $108 2021-12-16 Buy
Product number Packaging Price Buy
14693 1mg $44 Buy
14693 10mg $183 Buy
14693 50mg $745 Buy
1209 50 $1092 Buy
1209 1 $108 Buy

LY 341495 Chemical Properties,Uses,Production

Uses

LY-341495 is a potent and selective group II metabotropic glutamate receptor (mGluR) antagonist.

Uses

LY 341495 is a potent and selective antagonist of the group II metabotropic glutamate receptors (mGluR), mGluR2 and mGluR3 (IC50s = 21 and 14 nM, respectively, for human isoforms). It less effectively blocks mGluR8 and mGluR7 (IC50s = 173 and 990 nM, respectively) and weakly antagonizes mGluR1, mGluR5, and mGluR4 (IC50s = 6.8, 8.2, and 22 μM, respectively). In rat forebrain tissue, LY341495 may bind mGluR3 more avidly than mGluR2. LY341495 can be effectively used in isolated cells, tissues, and in vivo. In mice, it penetrates the blood-brain barrier and has been used to study the roles of mGlu2/3 receptors in the brain.[Cayman Chemical]

Definition

ChEBI: (1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-1-cyclopropanecarboxylic acid is a member of xanthenes.

Biological Activity

Highly potent and selective group II metabotropic glutamate receptor antagonist (K i /IC 50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu 2 , mGlu 3 , mGlu 8 , mGlu 7a , mGlu 1a , mGlu 5a and mGlu 4a receptors respectively). Readily brain penetrant and active in vivo . Also available as part of the Group II mGlu Receptor Tocriset™ , Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .

storage

Room temperature

References

[1] kingston a e, ornstein p l, wright r a, et al. ly341495 is a nanomolar potent and selective antagonist of group ii metabotropic glutamate receptors. neuropharmacology, 1998, 37(1): 1-12.
[2] fitzjohn s m, bortolotto z a, palmer m j, et al. the potent mglu receptor antagonist ly341495 identifies roles for both cloned and novel mglu receptors in hippocampal synaptic plasticity. neuropharmacology, 1998, 37(12): 1445-1458.
[3] pitsikas n, kaffe e, markou a. the metabotropic glutamate 2/3 receptor antagonist ly341495 differentially affects recognition memory in rats. behavioural brain research, 2012, 230(2): 374-379.

LY 341495 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 93)Suppliers
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CONIER CHEM AND PHARMA LIMITED
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LY 341495 (2S)-2-AMINO-2-[(1S,2S)-2-CARBOXYCYCLOPROP-1-YL]-3-(XANTH-9-YL) PROPANOIC ACID (alphaS)-alpha-Amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid LY 341495 (alphaS)-alpha-Amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid CS-416 (1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic acid LY 341495;LY-341495 9H-Xanthene-9-propanoic acid, α-amino-α-[(1S,2S)-2-carboxycyclopropyl]-, (αS)- 201943-63-7 Glutamate