6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one
- CAS No.
- 26246-41-3
- Chemical Name:
- 6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one
- Synonyms
- K 251-1;Reticulol;Nsc 294978;6,8-Dihydroxy-7-methoxy-3-methylisocoumarin;6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one;1H-2-Benzopyran-1-one, 6,8-dihydroxy-7-methoxy-3-methyl-
- CBNumber:
- CB02179856
- Molecular Formula:
- C11H10O5
- Molecular Weight:
- 222.19
- MDL Number:
- MOL File:
- 26246-41-3.mol
- MSDS File:
- SDS
| Melting point | 193-193.5℃ |
|---|---|
| Boiling point | 473.2±45.0 °C(Predicted) |
| Density | 1.424±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 7.19±0.20(Predicted) |
| form | A powder |
| color | White to off-white |
| FDA UNII | E2RA5C4YRR |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P302+P352-P305+P351+P338-P321-P330-P362+P364-P337+P313-P501 | |||||||||
| NFPA 704 |
|
6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23148 | Reticulol >95% | 26246-41-3 | 500μg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 23148 | Reticulol >95% | 26246-41-3 | 1mg | $146 | 2024-03-01 | Buy |
| Cayman Chemical | 23148 | Reticulol >95% | 26246-41-3 | 5mg | $679 | 2024-03-01 | Buy |
| Usbiological | R1650-35 | Reticulol | 26246-41-3 | 1mg | $426 | 2021-12-16 | Buy |
| TRC | R188508 | Reticulol | 26246-41-3 | 250μg | $85 | 2021-12-16 | Buy |
6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one Chemical Properties,Uses,Production
Description
Reticulol is an isocoumarin derivative produced by certain species of Streptomyces that inhibits cAMP phosphodiesterase (IC50 = 41 μM). It also inhibits DNA topoisomerase I when used at a concentration of 45 μM in B16F10 melanoma cells. Reticulol has antifungal activity against T. mentagrophyes with a MIC of 1.8 μM. It is cytotoxic against A427 human lung and B16F10 mouse melanoma cells at concentrations of 25 and 200 μM, respectively, and inhibits lung metastasis in mice.
Uses
Reticulol is an isocoumarin metabolite shown to inactivate topoisomerase I.
Uses
Reticulol is an isocoumarin metabolite produced by selected species of Streptomyces. Reticulol was first described as a potent inhibitor of cyclic nucleotide phosphodiesterase but more recent research has demonstrated a topoisomerase I inactivation mechanism. Reticulol also causes dose dependent inhibition of lung metastasis in the B16F10 melanoma model.
storage
+4°C
6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 56086 | 58 |
| Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8864 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44844 | 58 |